| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Final Destination | $1,914,102 | - | 90 | - | $21,267 | $1,914,102 | 1 | Roadshow Films | true | false |
| 2 | 1 | Couples Retreat | $1,775,996 | -33.8% | 221 | +4 | $8,036 | $5,498,271 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 3 | Mao's Last Dancer | $1,444,100 | -21.5% | 265 | -2 | $5,449 | $8,223,999 | 3 | Roadshow Films | false | false |
| 4 | 4 | Julie & Julia | $1,094,411 | -18.1% | 288 | +3 | $3,800 | $3,647,965 | 2 | Sony Pictures Releasing | false | false |
| 5 | 2 | Up | $999,483 | -47.3% | 269 | -86 | $3,715 | $24,946,198 | 7 | Buena Vista International | false | false |
| 6 | - | Astro Boy | $825,805 | - | 205 | - | $4,028 | $1,075,916 | 1 | Hoyts Distribution | true | false |
| 7 | 5 | G-Force | $613,763 | -52.8% | 255 | -72 | $2,406 | $9,464,194 | 5 | Walt Disney Pictures | false | false |
| 8 | 7 | Whip It | $358,226 | -25.3% | 152 | - | $2,356 | $1,071,007 | 2 | Roadshow Films | false | false |
| 9 | 6 | Surrogates | $304,544 | -41.1% | 174 | -7 | $1,750 | $4,677,616 | 4 | Walt Disney Pictures | false | false |
| 10 | 8 | Fame | $241,940 | -47.2% | 215 | -73 | $1,125 | $4,989,667 | 4 | Icon Film Distribution | false | false |
| 11 | 10 | Inglourious Basterds | $126,666 | -31.5% | 81 | -26 | $1,563 | $12,348,238 | 9 | Universal Pictures International (UPI) | false | false |
| 12 | - | Whatever Works | $118,602 | - | 28 | - | $4,235 | $139,990 | 1 | Hopscotch Films | true | false |
| 13 | 14 | Moon | $115,992 | -11.2% | 13 | - | $8,922 | $304,788 | 2 | Sony Pictures Releasing | false | false |
| 14 | 9 | 500 Days of Summer | $113,129 | -50.9% | 92 | -61 | $1,229 | $4,230,539 | 5 | 20th Century Fox International | false | false |
| 15 | 11 | Funny People | $95,869 | -41.7% | 98 | -17 | $978 | $5,927,006 | 6 | Universal Pictures International (UPI) | false | false |
| 16 | - | Blue | $90,234 | - | 16 | - | $5,639 | $90,234 | 1 | - | true | false |
| 17 | 13 | Aliens in the Attic | $85,979 | -42.1% | 85 | -44 | $1,011 | $3,686,961 | 7 | 20th Century Fox International | false | false |
| 18 | 16 | Charlie & Boots | $67,114 | -21.7% | 60 | -30 | $1,118 | $3,336,581 | 7 | Paramount Pictures International | false | false |
| 19 | 15 | Shorts | $57,222 | -48.9% | 64 | -45 | $894 | $1,076,560 | 5 | Warner Bros. | false | false |
| 20 | - | Departures | $50,002 | - | 11 | - | $4,545 | $64,286 | 1 | Madman Entertainment | true | false |
| 21 | - | An Education | $42,047 | - | 53 | - | $793 | $42,047 | - | Paramount Pictures International | - | false |
| 22 | - | Me and Mrs. Khanna | $41,423 | - | 12 | - | $3,451 | $41,423 | 1 | Mind Blowing Films | true | false |
| 23 | - | All the Best: Fun Begins | $10,702 | - | 6 | - | $1,783 | $10,702 | 1 | Mind Blowing Films | true | false |
| 24 | - | The Damned United | $10,208 | - | 1 | - | $10,208 | $10,208 | 1 | Sony Pictures Releasing | true | false |
| 25 | - | In Search of Beethoven | $3,022 | - | 5 | - | $604 | $3,022 | 1 | Gil Scrine Films | true | false |
