| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 14 | Cloudy with a Chance of Meatballs | $885,141 | +1,925.3% | 250 | +248 | $3,540 | $5,192,449 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | District 9 | $867,927 | - | 194 | - | $4,473 | $974,760 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Inglourious Basterds | $643,415 | -30.8% | 167 | -12 | $3,852 | $2,257,868 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 2 | The Ugly Truth | $528,135 | -22.7% | 163 | -1 | $3,240 | $5,692,879 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | The Time Traveler's Wife | $420,696 | - | 139 | - | $3,026 | $420,696 | 1 | PlayArte Pictures | true | false |
| 6 | 3 | The Hangover | $301,622 | -23.3% | 179 | -1 | $1,685 | $7,717,826 | 9 | Warner Bros. | false | false |
| 7 | - | The Rebound | $264,889 | - | 85 | - | $3,116 | $264,889 | 1 | N/A | true | false |
| 8 | 4 | Up | $226,461 | -33% | 235 | -19 | $963 | $10,245,653 | 7 | Walt Disney Pictures | false | false |
| 9 | 5 | So Normal 2: The Craziest Night Ever | $156,630 | -46.4% | 220 | -81 | $711 | $10,277,845 | 8 | N/A | false | false |
| 10 | 6 | Time of Fear | $141,551 | -43.3% | 140 | -31 | $1,011 | $1,185,871 | 3 | Sony Pictures Releasing | false | false |
| 11 | - | The Informant! | $135,977 | - | 32 | - | $4,249 | $135,977 | 1 | Warner Bros. | true | false |
| 12 | 8 | The Taking of Pelham 123 | $81,647 | -34.2% | 144 | -10 | $566 | $4,113,129 | 7 | Sony Pictures Releasing | false | false |
| 13 | 7 | 9 | $64,482 | -67.9% | 141 | - | $457 | $475,011 | 2 | PlayArte Pictures | false | false |
| 14 | 15 | Aliens in the Attic | $36,401 | -9.9% | 82 | - | $443 | $493,214 | 4 | 20th Century Fox International | false | false |
| 15 | 16 | Spread | $33,933 | +13.3% | 34 | - | $998 | $435,714 | 4 | N/A | false | false |
| 16 | 12 | My Sister's Keeper | $30,933 | -38.7% | 69 | -8 | $448 | $1,175,619 | 6 | PlayArte Pictures | false | false |
| 17 | 9 | Gamer | $28,077 | -74.9% | 76 | -17 | $369 | $603,074 | 3 | N/A | false | false |
| 18 | 11 | Whiteout | $23,073 | -57.6% | 44 | -5 | $524 | $285,899 | 3 | Warner Bros. | false | false |
| 19 | 10 | The Dolphin: Story of a Dreamer | $21,936 | -63.2% | 63 | -1 | $348 | $170,718 | 2 | 20th Century Fox International | false | false |
| 20 | 13 | Herbert de Perto | $13,861 | -69% | 22 | -9 | $630 | $90,293 | 2 | N/A | false | false |
| 21 | 17 | G-Force | $13,254 | -47.9% | 88 | -57 | $150 | $4,335,724 | 10 | Walt Disney Pictures | false | false |
| 22 | 18 | Orphan | $13,245 | -45.9% | 33 | -19 | $401 | $814,780 | 7 | Warner Bros. | false | false |
| 23 | 19 | Two Lovers | $7,345 | -68.5% | 21 | -5 | $349 | $667,097 | 8 | PlayArte Pictures | false | false |
| 24 | 20 | Che: Part Two | $6,764 | -60% | 17 | -7 | $397 | $102,281 | 5 | Europa Filmes | false | false |
| 25 | 23 | My Life in Ruins | $5,364 | -39.9% | 41 | -10 | $130 | $812,423 | 6 | N/A | false | false |
| 26 | 22 | Sorority Row | $4,940 | -50.6% | 26 | -6 | $190 | $297,916 | 4 | Paris Filmes | false | false |
| 27 | 24 | Ice Age: Dawn of the Dinosaurs | $3,647 | -43.9% | 37 | -27 | $98 | $45,373,371 | 16 | 20th Century Fox International | false | false |
| 28 | 25 | The Proposal | $3,108 | -5.5% | 6 | -1 | $518 | $7,342,754 | 15 | Walt Disney Pictures | false | false |
| 29 | 21 | Shorts | $2,902 | -73.8% | 18 | -24 | $161 | $287,452 | 8 | Warner Bros. | false | false |
| 30 | 26 | Bandslam | $1,411 | -47.6% | 14 | -12 | $100 | $144,436 | 6 | Paris Filmes | false | false |
| 31 | 30 | Brüno | $955 | -10.5% | 9 | +2 | $106 | $1,169,280 | 10 | Sony Pictures Releasing | false | false |
