| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inglourious Basterds | $36,536 | -20.3% | 8 | - | $4,567 | $87,796 | 2 | United International Pictures | false | false |
| 2 | 3 | The Ugly Truth | $16,208 | -16.2% | 6 | - | $2,701 | $158,658 | 5 | Sony Pictures Releasing | false | false |
| 3 | 2 | Surrogates | $15,456 | -23.8% | 6 | - | $2,576 | $79,055 | 3 | Walt Disney Pictures | false | false |
| 4 | - | Funny People | $12,437 | - | 5 | - | $2,487 | $12,437 | 1 | United International Pictures | true | false |
| 5 | 4 | The Final Destination | $12,408 | -19% | 5 | - | $2,481 | $207,081 | 6 | Warner Bros. | false | false |
| 6 | - | Arn: The Knight Templar | $12,177 | - | 5 | - | $2,435 | $12,177 | 1 | - | true | false |
| 7 | - | Whiteout | $11,232 | - | 5 | - | $2,246 | $11,232 | 1 | Warner Bros. | true | false |
| 8 | 5 | Orphan | $10,710 | -17.3% | 5 | - | $2,142 | $73,348 | 4 | Warner Bros. | false | false |
| 9 | 6 | I Hate Valentine's Day | $6,806 | -35.9% | 3 | - | $2,268 | $18,855 | 2 | - | false | false |
| 10 | 8 | Jennifer's Body | $6,508 | -12.2% | 3 | - | $2,169 | $28,969 | 3 | 20th Century Fox International | false | false |
| 11 | 7 | Red Cliff | $4,977 | -33.1% | 4 | -1 | $1,244 | $26,119 | 3 | - | false | false |
| 12 | 9 | Land of the Lost | $3,588 | -21.1% | 6 | - | $598 | $31,502 | 4 | United International Pictures | false | false |
| 13 | 12 | Gamer | $2,262 | -12.6% | 2 | -1 | $1,131 | $72,259 | 6 | - | false | false |
| 14 | 10 | G.I. Joe: The Rise of Cobra | $2,204 | -51.3% | 7 | -1 | $314 | $98,551 | 5 | United International Pictures | false | false |
| 15 | 16 | Cloudy with a Chance of Meatballs | $1,861 | +92.1% | 3 | +1 | $620 | $37,937 | 6 | Sony Pictures Releasing | false | false |
| 16 | 14 | The Flight Before Christmas | $1,492 | -15% | 2 | - | $746 | $3,385 | 2 | - | false | false |
| 17 | 11 | Blood: The Last Vampire | $995 | -70.9% | 3 | - | $331 | $5,116 | 2 | N/A | false | false |
| 18 | 15 | The Hangover | $655 | -36.7% | 1 | - | $655 | $182,942 | 13 | Warner Bros. | false | false |
| 19 | 17 | Imagine That | $591 | +5.2% | 2 | - | $295 | $64,083 | 12 | United International Pictures | false | false |
| 20 | 13 | The Other Man | $461 | -81.6% | 3 | -1 | $153 | $21,075 | 4 | N/A | false | false |
| 21 | - | Public Enemies | $49 | - | 1 | - | $49 | $133,686 | 13 | United International Pictures | false | false |
| 22 | 19 | Aliens in the Attic | $27 | -15.6% | 1 | - | $27 | $9,379 | 4 | 20th Century Fox International | false | false |
