| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cloudy with a Chance of Meatballs | $44,758 | - | 10 | - | $4,475 | $44,758 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | G-Force | $12,722 | -38.3% | 13 | - | $978 | $152,530 | 4 | - | false | false |
| 3 | 1 | Surrogates | $11,828 | -48.2% | 4 | - | $2,957 | $46,634 | 2 | - | false | false |
| 4 | 3 | The Ugly Truth | $11,648 | -18.1% | 4 | - | $2,912 | $162,794 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | Orphan | $6,902 | - | 3 | - | $2,300 | $6,902 | 1 | ACME | true | false |
| 6 | 4 | The Time Traveler's Wife | $6,832 | -21% | 1 | - | $6,832 | $22,367 | 2 | - | false | false |
| 7 | - | Antichrist | $6,807 | - | 1 | - | $6,807 | $6,807 | 1 | ACME | true | false |
| 8 | 6 | Julie & Julia | $6,310 | -11.3% | 1 | - | $6,310 | $33,754 | 3 | Sony Pictures Releasing | false | false |
| 9 | 7 | High Security Vacation | $3,891 | -26.1% | 2 | - | $1,945 | $109,240 | 9 | ACME | false | false |
| 10 | 8 | Inglourious Basterds | $3,503 | -31.5% | 3 | - | $1,167 | $187,268 | 10 | - | false | false |
| 11 | 5 | The Final Destination | $3,213 | -62.1% | 1 | - | $3,213 | $166,426 | 6 | - | false | false |
| 12 | 11 | Shrink | $2,972 | -9.3% | 1 | - | $2,972 | $25,599 | 4 | ACME | false | false |
| 13 | 10 | The Hurt Locker | $2,432 | -25.8% | 1 | - | $2,432 | $8,784 | 2 | ACME | false | false |
| 14 | 9 | Pandorum | $1,886 | -48.3% | 2 | - | $943 | $22,285 | 3 | ACME | false | false |
| 15 | 12 | Up | $1,303 | -47% | 9 | - | $144 | $255,663 | 12 | - | false | false |
| 16 | 16 | Spread | $1,111 | -32.2% | 1 | - | $1,111 | $104,926 | 10 | ACME | false | false |
| 17 | 14 | Ice Age: Dawn of the Dinosaurs | $1,052 | -53.9% | 12 | - | $87 | $818,618 | 17 | - | false | false |
| 18 | 15 | 9 | $587 | -69.9% | 2 | - | $293 | $25,883 | 4 | - | false | false |
| 19 | 17 | Fame | $446 | -62.2% | 2 | - | $223 | $23,060 | 5 | - | false | false |
| 20 | 18 | Coraline | $95 | -88.5% | 1 | - | $95 | $32,575 | 8 | - | false | false |
