| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | This Is It | $39,672 | - | 5 | - | $7,934 | $82,597 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Cloudy with a Chance of Meatballs | $37,185 | -58.1% | 8 | -2 | $4,648 | $206,960 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Saw VI | $30,799 | - | 7 | - | $4,399 | $30,799 | 1 | ACME | true | false |
| 4 | 3 | OceanWorld | $11,478 | -36% | 3 | - | $3,826 | $173,521 | 4 | ACME | false | false |
| 5 | 2 | Gamer | $7,160 | -61.1% | 6 | - | $1,193 | $34,845 | 2 | ACME | false | false |
| 6 | 4 | Low Lights | $6,389 | -59.7% | 4 | - | $1,597 | $32,689 | 2 | ACME | false | false |
| 7 | 5 | Whiteout | $4,942 | -63.8% | 7 | - | $706 | $74,710 | 3 | - | false | false |
| 8 | 6 | G-Force | $4,257 | -55.1% | 7 | -2 | $608 | $293,278 | 7 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Surrogates | $3,143 | -60.8% | 6 | +1 | $523 | $94,315 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Broken Embraces | $3,140 | -62.5% | 3 | - | $1,046 | $33,817 | 3 | ACME | false | false |
| 11 | 9 | The Ugly Truth | $2,150 | -65.2% | 2 | -1 | $1,075 | $225,952 | 8 | Sony Pictures Releasing | false | false |
| 12 | 16 | Inglourious Basterds | $1,089 | -5.1% | 1 | - | $1,089 | $178,743 | 10 | Universal Pictures International (UPI) | false | false |
| 13 | 13 | 9 | $756 | -51% | 3 | - | $252 | $33,765 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 14 | The Final Destination | $626 | -56.2% | 3 | - | $208 | $218,262 | 9 | - | false | false |
| 15 | 11 | Jennifer's Body | $538 | -70.6% | 2 | -2 | $269 | $47,170 | 5 | Universal Pictures International (UPI) | false | false |
| 16 | 10 | Orphan | $536 | -76.4% | 4 | +1 | $134 | $85,079 | 6 | - | false | false |
| 17 | 12 | Up | $465 | -74.4% | 2 | -4 | $232 | $431,727 | 11 | Universal Pictures International (UPI) | false | false |
| 18 | 18 | Whatever Works | $424 | +11.6% | 1 | - | $424 | $11,362 | 7 | ACME | false | false |
| 19 | - | Two Lovers | $277 | - | 1 | - | $277 | $6,235 | 5 | ACME | false | false |
| 20 | - | Bolt | $229 | - | 2 | - | $114 | $346,718 | 36 | Universal Pictures International (UPI) | false | false |
| 21 | 21 | Vortex | $206 | -8% | 2 | +1 | $103 | $44,661 | 21 | N/A | false | false |
| 22 | - | Lorna's Silence | $154 | - | 1 | - | $154 | $2,956 | 10 | N/A | false | false |
