| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | This Is It | $55,880 | - | 6 | - | $9,313 | $55,880 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Cloudy with a Chance of Meatballs | $25,467 | -43.1% | 10 | - | $2,546 | $105,937 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Saw VI | $21,654 | - | 3 | - | $7,218 | $21,654 | 1 | ACME | true | false |
| 4 | 2 | G-Force | $9,283 | -27% | 13 | - | $714 | $176,786 | 5 | - | false | false |
| 5 | 4 | The Ugly Truth | $8,248 | -29.2% | 4 | - | $2,062 | $177,602 | 6 | Sony Pictures Releasing | false | false |
| 6 | 5 | Orphan | $6,007 | -13% | 3 | - | $2,002 | $21,929 | 2 | ACME | false | false |
| 7 | 3 | Surrogates | $5,908 | -50.1% | 4 | - | $1,477 | $58,877 | 3 | - | false | false |
| 8 | - | 3 of Us | $5,904 | - | 1 | - | $5,904 | $5,904 | 1 | N/A | true | false |
| 9 | 11 | The Final Destination | $5,360 | +66.8% | 1 | - | $5,360 | $171,887 | 7 | - | false | false |
| 10 | 7 | Antichrist | $4,216 | -38.1% | 1 | - | $4,216 | $16,476 | 2 | ACME | false | false |
| 11 | 8 | Julie & Julia | $3,943 | -37.5% | 1 | - | $3,943 | $41,042 | 4 | Sony Pictures Releasing | false | false |
| 12 | 6 | The Time Traveler's Wife | $3,231 | -52.7% | 1 | - | $3,231 | $30,867 | 3 | - | false | false |
| 13 | 12 | Shrink | $1,929 | -35.1% | 1 | - | $1,929 | $28,533 | 5 | ACME | false | false |
| 14 | 15 | Up | $1,543 | +18.4% | 9 | - | $171 | $253,368 | 13 | - | false | false |
| 15 | 9 | High Security Vacation | $1,310 | -66.3% | 2 | - | $655 | $110,037 | 10 | ACME | false | false |
| 16 | 17 | Ice Age: Dawn of the Dinosaurs | $1,058 | +0.6% | 12 | - | $88 | $802,797 | 18 | - | false | false |
| 17 | 14 | Pandorum | $872 | -53.8% | 2 | - | $436 | $23,317 | 4 | ACME | false | false |
| 18 | 13 | The Hurt Locker | $729 | -70% | 1 | - | $729 | $10,814 | 3 | ACME | false | false |
| 19 | 10 | Inglourious Basterds | $523 | -85.1% | 3 | - | $174 | $185,532 | 11 | - | false | false |
