| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Surrogates | $12,062 | - | 4 | - | $3,015 | $15,723 | 1 | Walt Disney Pictures | true | false |
| 2 | - | This Is It | $11,567 | - | 3 | - | $3,855 | $11,567 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Wait for Me and I Will Not Come | $8,465 | -34.9% | 7 | - | $1,209 | $93,271 | 3 | N/A | false | false |
| 4 | 3 | Cloudy with a Chance of Meatballs | $6,869 | -24.5% | 6 | -1 | $1,144 | $17,776 | 2 | Sony Pictures Releasing | false | false |
| 5 | 2 | Ice Age: Dawn of the Dinosaurs | $6,476 | -44% | 9 | - | $719 | $472,306 | 18 | 20th Century Fox International | false | false |
| 6 | 4 | The Ugly Truth | $5,321 | -26.5% | 6 | - | $886 | $114,956 | 8 | Sony Pictures Releasing | false | false |
| 7 | 5 | Up | $3,281 | -25.6% | 6 | - | $546 | $66,267 | 7 | Walt Disney Pictures | false | false |
| 8 | 6 | Devil's Town | $2,307 | -43.8% | 5 | +1 | $461 | $43,711 | 4 | N/A | false | false |
| 9 | 8 | Inglourious Basterds | $1,660 | -38.1% | 6 | - | $276 | $201,135 | 11 | United International Pictures | false | false |
| 10 | 11 | Superhero Movie | $1,496 | +3.6% | 1 | - | $1,496 | $11,676 | 9 | N/A | false | false |
| 11 | 9 | District 9 | $1,155 | -55.8% | 6 | - | $192 | $46,796 | 5 | N/A | false | false |
| 12 | 7 | The Final Destination | $1,124 | -59.5% | 4 | - | $281 | $51,987 | 7 | Warner Bros. | false | false |
| 13 | 13 | The Taking of Pelham 123 | $753 | +3.6% | 4 | - | $188 | $43,696 | 10 | Sony Pictures Releasing | false | false |
| 14 | 10 | The True Story of Puss'N Boots | $399 | -74.5% | 4 | - | $99 | $8,494 | 6 | N/A | false | false |
| 15 | 21 | The Proposal | $299 | +131.8% | 6 | - | $49 | $111,583 | 15 | Walt Disney Pictures | false | false |
| 16 | 16 | The Hangover | $298 | -45.3% | 5 | - | $59 | $151,887 | 20 | Warner Bros. | false | false |
| 17 | 17 | G.I. Joe: The Rise of Cobra | $248 | -36.1% | 6 | - | $41 | $27,563 | 6 | United International Pictures | false | false |
| 18 | 14 | The Brothers Bloom | $216 | -65.3% | 3 | - | $72 | $14,730 | 6 | N/A | false | false |
| 19 | 20 | Public Enemies | $142 | -9% | 5 | - | $28 | $80,904 | 18 | United International Pictures | false | false |
| 20 | 19 | Two Lovers | $94 | -47.5% | 3 | - | $31 | $14,515 | 10 | N/A | false | false |
| 21 | 18 | G-Force | $93 | -68.4% | 5 | - | $18 | $32,102 | 10 | Walt Disney Pictures | false | false |
