| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | This Is It | $468,985 | - | 81 | - | $5,789 | $468,985 | 1 | N/A | true | false |
| 2 | 2 | The Ugly Truth | $83,211 | -29.6% | 54 | - | $1,540 | $806,430 | 4 | N/A | false | false |
| 3 | 1 | Inglourious Basterds | $81,756 | -40.6% | 59 | - | $1,385 | $284,226 | 2 | N/A | false | false |
| 4 | 3 | Cloudy with a Chance of Meatballs | $78,842 | -32% | 69 | - | $1,142 | $356,492 | 3 | N/A | false | false |
| 5 | 4 | Up | $37,344 | -37.2% | 59 | +1 | $632 | $1,812,456 | 8 | Ster-Kinekor Pictures | false | false |
| 6 | 5 | Gamer | $35,859 | -30.2% | 35 | - | $1,024 | $110,446 | 2 | N/A | false | false |
| 7 | 6 | The Final Destination | $31,143 | -34.5% | 33 | -2 | $943 | $491,245 | 5 | N/A | false | false |
| 8 | 9 | Jennifer's Body | $25,660 | -23.9% | 25 | - | $1,026 | $129,352 | 3 | N/A | false | false |
| 9 | 7 | The Taking of Pelham 123 | $24,759 | -45.2% | 46 | -16 | $538 | $763,136 | 6 | N/A | false | false |
| 10 | 10 | Imagine That | $19,826 | -26.3% | 31 | -10 | $639 | $437,077 | 6 | N/A | false | false |
| 11 | 11 | Fame | $13,441 | -41.9% | 32 | -16 | $420 | $579,727 | 6 | N/A | false | false |
| 12 | 13 | Aliens in the Attic | $12,432 | -36.8% | 17 | -3 | $731 | $151,312 | 5 | N/A | false | false |
| 13 | - | Whatever Works | $12,162 | - | 11 | - | $1,105 | $12,162 | 1 | N/A | true | false |
| 14 | - | Pandorum | $12,148 | - | 15 | - | $809 | $12,148 | 1 | N/A | true | false |
| 15 | 12 | Last Chance Harvey | $11,245 | -42.9% | 13 | -1 | $865 | $180,223 | 5 | N/A | false | false |
| 16 | 14 | The Informant! | $8,519 | -41.2% | 13 | -2 | $655 | $61,818 | 3 | N/A | false | false |
| 17 | 16 | The Proposal | $8,112 | -17.6% | 13 | -1 | $624 | $2,631,303 | 17 | Ster-Kinekor Pictures | false | false |
| 18 | 15 | Blood: The Last Vampire | $7,108 | -39.3% | 13 | -7 | $546 | $95,225 | 4 | N/A | false | false |
| 19 | 19 | Dance Flick | $1,844 | -22.4% | 6 | - | $307 | $71,447 | 8 | United International Pictures | false | false |
| 20 | 18 | G.I. Joe: The Rise of Cobra | $1,640 | -53% | 5 | -3 | $328 | $1,345,701 | 12 | United International Pictures | false | false |
| 21 | 20 | Public Enemies | $388 | -75.9% | 3 | -2 | $129 | $401,466 | 9 | United International Pictures | false | false |
| 22 | 22 | Disgrace | $155 | -21.3% | 1 | - | $155 | $68,924 | 12 | United International Pictures | false | false |
| 23 | 21 | Looking for Eric | $138 | -88.5% | 1 | -3 | $138 | $23,506 | 4 | N/A | false | false |
