| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | My Life in Ruins | $15,071 | - | 5 | - | $3,014 | $19,130 | 1 | N/A | true | false |
| 2 | 1 | Surrogates | $8,061 | -33.2% | 4 | - | $2,015 | $29,641 | 2 | Walt Disney Pictures | false | false |
| 3 | - | Broken Embraces | $5,336 | - | 5 | - | $1,067 | $21,125 | 1 | N/A | true | false |
| 4 | 4 | Cloudy with a Chance of Meatballs | $4,557 | -33.7% | 6 | - | $759 | $23,773 | 3 | Sony Pictures Releasing | false | false |
| 5 | 5 | Ice Age: Dawn of the Dinosaurs | $4,178 | -35.5% | 9 | - | $464 | $478,631 | 19 | 20th Century Fox International | false | false |
| 6 | 2 | This Is It | $4,045 | -65% | 3 | - | $1,348 | $17,432 | 2 | Sony Pictures Releasing | false | false |
| 7 | 6 | The Ugly Truth | $3,499 | -34.2% | 6 | - | $583 | $120,503 | 9 | Sony Pictures Releasing | false | false |
| 8 | 9 | Inglourious Basterds | $1,766 | +6.4% | 6 | - | $294 | $203,983 | 12 | United International Pictures | false | false |
| 9 | 7 | Up | $1,765 | -46.2% | 6 | - | $294 | $69,024 | 8 | Walt Disney Pictures | false | false |
| 10 | 12 | The Final Destination | $1,258 | +11.9% | 4 | - | $314 | $53,956 | 8 | Warner Bros. | false | false |
| 11 | 8 | Devil's Town | $829 | -64.1% | 5 | - | $165 | $44,540 | 5 | N/A | false | false |
| 12 | 19 | Public Enemies | $315 | +121.8% | 5 | - | $63 | $81,270 | 19 | United International Pictures | false | false |
| 13 | 18 | The Brothers Bloom | $254 | +17.6% | 3 | - | $84 | $15,160 | 7 | N/A | false | false |
| 14 | 14 | The True Story of Puss'N Boots | $224 | -43.9% | 4 | - | $56 | $8,870 | 7 | N/A | false | false |
| 15 | 15 | The Proposal | $110 | -63.2% | 6 | - | $18 | $111,731 | 16 | Walt Disney Pictures | false | false |
| 16 | 17 | G.I. Joe: The Rise of Cobra | $78 | -68.5% | 6 | - | $13 | $27,707 | 7 | United International Pictures | false | false |
| 17 | 16 | The Hangover | $64 | -78.5% | 5 | - | $12 | $152,208 | 21 | Warner Bros. | false | false |
| 18 | 20 | Two Lovers | $42 | -55.3% | 3 | - | $14 | $14,610 | 11 | N/A | false | false |
| 19 | 13 | The Taking of Pelham 123 | $29 | -96.1% | 3 | -1 | $9 | $43,933 | 11 | Sony Pictures Releasing | false | false |
| 20 | 21 | G-Force | $16 | -82.8% | 5 | - | $3 | $32,422 | 11 | Walt Disney Pictures | false | false |
