| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $7,647,027 | -20.2% | 493 | - | $15,511 | $65,702,512 | 4 | 20th Century Fox International | false | false |
| 2 | 2 | Sherlock Holmes | $3,248,489 | -41.5% | 486 | +2 | $6,684 | $25,126,727 | 3 | Warner Bros. | false | false |
| 3 | - | Daybreakers | $2,155,134 | - | 378 | - | $5,701 | $2,155,134 | 1 | Lionsgate Films | true | false |
| 4 | 3 | Alvin and the Chipmunks: The Squeakquel | $1,955,876 | -50.7% | 489 | - | $3,999 | $24,052,935 | 3 | 20th Century Fox International | false | false |
| 5 | - | It's Complicated | $1,760,954 | - | 434 | - | $4,057 | $1,760,954 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | The Road | $1,005,204 | - | 157 | - | $6,402 | $1,005,204 | 1 | Icon Film Distribution | true | false |
| 7 | - | Did You Hear About the Morgans? | $895,039 | - | 397 | - | $2,254 | $3,602,100 | - | Sony Pictures Releasing | - | false |
| 8 | 5 | Nine | $542,481 | -56.9% | 369 | -15 | $1,470 | $3,849,947 | 7 | Entertainment Film Distributors | false | false |
| 9 | 6 | St Trinian's 2: The Legend of Fritton's Gold | $471,075 | -56.5% | 390 | -26 | $1,207 | $9,908,849 | 4 | Entertainment Film Distributors | false | false |
| 10 | - | Sex & Drugs & Rock & Roll | $278,620 | - | 131 | - | $2,126 | $278,620 | 1 | Entertainment Film Distributors | true | false |
| 11 | - | 3 Idiots | $224,792 | - | 52 | - | $4,322 | $2,195,567 | - | - | - | false |
| 12 | 9 | The Twilight Saga: New Moon | $153,251 | -56% | 128 | -66 | $1,197 | $43,409,449 | 8 | Entertainment One | false | false |
| 13 | 10 | Planet 51 | $126,927 | -51.9% | 260 | -67 | $488 | $7,098,756 | 8 | Entertainment Film Distributors | false | false |
| 14 | 8 | Nowhere Boy | $123,579 | -67.5% | 97 | -79 | $1,274 | $1,553,087 | 3 | Icon Film Distribution | false | false |
| 15 | - | Dulha Mil Gaya | $115,018 | - | 48 | - | $2,396 | $115,018 | 1 | N/A | true | false |
