| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $5,049,845 | -21.9% | 420 | -31 | $12,023 | $76,415,255 | 6 | 20th Century Fox International | false | false |
| 2 | 2 | Tooth Fairy | $1,889,454 | -21.6% | 243 | - | $7,775 | $6,010,458 | 2 | 20th Century Fox International | false | false |
| 3 | - | Invictus | $1,577,894 | - | 261 | - | $6,045 | $1,614,259 | 1 | Warner Bros. | true | false |
| 4 | 3 | It's Complicated | $1,462,899 | -34.4% | 303 | - | $4,828 | $9,470,157 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 5 | Up in the Air | $1,099,750 | -31.4% | 147 | -26 | $7,481 | $3,326,611 | 2 | Paramount Pictures International | false | false |
| 6 | 4 | Sherlock Holmes | $1,044,643 | -35.5% | 271 | -17 | $3,854 | $20,826,805 | 5 | Roadshow Films | false | false |
| 7 | 6 | Bran Nue Dae | $974,438 | -34.5% | 232 | +1 | $4,200 | $3,324,854 | 2 | Roadshow Films | false | false |
| 8 | 7 | Alvin and the Chipmunks: The Squeakquel | $886,692 | -33% | 289 | -34 | $3,068 | $19,396,690 | 5 | 20th Century Fox International | false | false |
| 9 | - | Nine | $694,371 | - | 133 | - | $5,220 | $734,330 | 1 | Sony Pictures Releasing | true | false |
| 10 | 8 | The Princess and the Frog | $451,004 | -29.9% | 223 | -5 | $2,022 | $5,418,721 | 4 | Walt Disney Pictures | false | false |
| 11 | - | Toy Story 2009 Re-release | $308,669 | - | 125 | - | $2,469 | $308,669 | 1 | Walt Disney Pictures | true | false |
| 12 | 9 | Old Dogs | $272,391 | -51.9% | 165 | -71 | $1,650 | $8,231,291 | 5 | Walt Disney Pictures | false | false |
| 13 | 10 | The Lovely Bones | $271,736 | -46% | 160 | -22 | $1,698 | $5,390,876 | 5 | Paramount Pictures International | false | false |
| 14 | 11 | Fantastic Mr. Fox | $231,833 | -35.9% | 155 | -61 | $1,495 | $3,234,124 | 10 | 20th Century Fox International | false | false |
| 15 | - | In the Loop | $89,488 | - | 18 | - | $4,971 | $181,832 | 1 | Madman Entertainment | true | false |
| 16 | 13 | Bright Star | $84,986 | -43.3% | 42 | -22 | $2,023 | $2,208,055 | 5 | Hopscotch Films | false | false |
| 17 | 15 | Nowhere Boy | $66,656 | +12.5% | 35 | +1 | $1,904 | $807,879 | 5 | Icon Film Distribution | false | false |
| 18 | - | An Education | $63,273 | - | 8 | - | $7,909 | $1,491,386 | 14 | Paramount Pictures International | false | false |
| 19 | 12 | Did You Hear About the Morgans? | $60,626 | -72.2% | 60 | -106 | $1,010 | $5,507,073 | 5 | Sony Pictures Releasing | false | false |
| 20 | - | Veer | $57,168 | - | 11 | - | $5,197 | $57,168 | 1 | Eros Worldwide | true | false |
