| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $2,187,381 | -21.3% | 472 | -8 | $4,634 | $31,842,784 | 5 | 20th Century Fox International | false | false |
| 2 | - | Tooth Fairy | $1,869,695 | - | 500 | - | $3,739 | $1,869,695 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Sherlock Holmes | $1,088,938 | -40.1% | 460 | -178 | $2,367 | $8,952,657 | 3 | Warner Bros. | false | false |
| 4 | 3 | Alvin and the Chipmunks: The Squeakquel | $530,961 | -42.4% | 435 | -21 | $1,220 | $9,177,646 | 4 | 20th Century Fox International | false | false |
| 5 | - | Did You Hear About the Morgans? | $460,222 | - | 216 | - | $2,130 | $460,222 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | Paranormal Activity | $363,479 | -33.6% | 285 | -64 | $1,275 | $4,944,377 | 4 | Gussi Films | false | false |
| 7 | 5 | Law Abiding Citizen | $316,061 | -35% | 243 | -9 | $1,300 | $1,098,913 | 2 | N/A | false | false |
| 8 | 6 | Zombieland | $153,732 | -46% | 181 | -19 | $849 | $608,532 | 2 | Sony Pictures Releasing | false | false |
| 9 | 15 | Case 39 | $133,800 | +137.9% | 126 | +55 | $1,061 | $3,069,359 | 7 | Paramount Pictures International | false | false |
| 10 | - | Fame | $124,238 | - | 151 | - | $822 | $124,300 | 1 | N/A | true | false |
| 11 | - | Ninja Assassin | $109,872 | - | 120 | - | $915 | $109,872 | 1 | Warner Bros. | true | false |
| 12 | 7 | The Princess and the Frog | $105,466 | -58.9% | 170 | -158 | $620 | $5,938,213 | 6 | Walt Disney Pictures | false | false |
| 13 | 12 | Everybody's Fine | $105,407 | +4.6% | 106 | +25 | $994 | $1,082,859 | 4 | Walt Disney Pictures | false | false |
| 14 | - | Pandorum | $84,311 | - | 100 | - | $843 | $84,311 | 1 | Gussi Films | true | false |
| 15 | 8 | Labor Pains | $82,284 | -64% | 162 | -20 | $507 | $445,225 | 2 | N/A | false | false |
| 16 | 9 | The Box | $80,159 | -48% | 107 | -50 | $749 | $1,213,173 | 6 | Videocine | false | false |
| 17 | 10 | The Stepfather | $53,494 | -47.5% | 82 | -26 | $652 | $436,436 | 6 | Sony Pictures Releasing | false | false |
| 18 | 11 | Old Dogs | $53,006 | -47.8% | 70 | -56 | $757 | $5,019,119 | 8 | Walt Disney Pictures | false | false |
| 19 | 14 | Mutant Chronicles | $33,416 | -65.6% | 96 | -34 | $348 | $196,506 | 2 | Videocine | false | false |
| 20 | 20 | New York, I Love You | $23,731 | +155.6% | 29 | +23 | $818 | $299,805 | 5 | N/A | false | false |
| 21 | 24 | Julie & Julia | $19,795 | +393.8% | 25 | +19 | $791 | $514,905 | 13 | Sony Pictures Releasing | false | false |
| 22 | 16 | Nikté | $13,111 | -62.3% | 35 | -115 | $374 | $1,280,500 | 5 | Universal Pictures International (UPI) | false | false |
| 23 | - | The Milk of Sorrow | $12,596 | - | 10 | - | $1,259 | $12,596 | 1 | N/A | true | false |
| 24 | 17 | The Twilight Saga: New Moon | $8,183 | -76.3% | 25 | -69 | $327 | $18,808,309 | 9 | N/A | false | false |
| 25 | 13 | All About Steve | $7,038 | -92.9% | 17 | -107 | $414 | $562,655 | 3 | 20th Century Fox International | false | false |
| 26 | 19 | Opium: Diary of a Madwoman | $6,130 | -56.2% | 9 | - | $681 | $29,739 | 2 | N/A | false | false |
| 27 | 18 | 2012 | $5,723 | -79.9% | 22 | -69 | $260 | $19,418,943 | 10 | Sony Pictures Releasing | false | false |
| 28 | 23 | Lemon Tree | $3,207 | -30.2% | 3 | - | $1,069 | $43,562 | 4 | N/A | false | false |
| 29 | 26 | Paris | $2,717 | +18.1% | 7 | +3 | $388 | $62,229 | 6 | N/A | false | false |
| 30 | 21 | Planet 51 | $1,767 | -76.7% | 9 | -28 | $196 | $4,590,034 | 8 | Videocine | false | false |
| 31 | 25 | Easy Virtue | $1,439 | -50.5% | 4 | -2 | $359 | $64,487 | 7 | Sony Pictures Releasing | false | false |
