| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $210,724 | -10.5% | 64 | -8 | $3,292 | $3,817,628 | 6 | 20th Century Fox International | false | false |
| 2 | 2 | Tooth Fairy | $188,158 | -16.5% | 36 | - | $5,226 | $524,689 | 2 | 20th Century Fox International | false | false |
| 3 | 4 | Alvin and the Chipmunks: The Squeakquel | $83,619 | -35% | 50 | - | $1,672 | $1,259,681 | 4 | 20th Century Fox International | false | false |
| 4 | - | Up in the Air | $70,919 | - | 14 | - | $5,065 | $70,919 | 1 | Paramount Pictures International | true | false |
| 5 | 3 | Sherlock Holmes | $70,739 | -48.1% | 48 | - | $1,473 | $691,566 | 3 | Warner Bros. | false | false |
| 6 | - | Ninja Assassin | $48,784 | - | 12 | - | $4,065 | $48,784 | 1 | Warner Bros. | true | false |
| 7 | - | Blackout 2009 Re-release | $48,699 | - | 15 | - | $3,246 | $48,699 | 1 | N/A | true | false |
| 8 | 5 | Cirque du Freak: The Vampire's Assistant | $38,888 | -49.6% | 30 | - | $1,296 | $157,742 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | [Rec]² | $26,727 | -50.5% | 26 | - | $1,027 | $448,954 | 4 | N/A | false | false |
| 10 | - | My Life in Ruins | $25,675 | - | 14 | - | $1,833 | $25,675 | 1 | N/A | true | false |
| 11 | 9 | Paranormal Activity | $15,873 | -58.9% | 25 | - | $634 | $659,774 | 5 | N/A | false | false |
| 12 | 8 | The Code | $15,798 | -61.4% | 19 | - | $831 | $76,426 | 2 | N/A | false | false |
| 13 | 12 | Couples Retreat | $14,717 | +167.5% | 26 | - | $566 | $322,054 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 6 | The Stepfather | $14,209 | -73.7% | 25 | - | $568 | $96,320 | 2 | Sony Pictures Releasing | false | false |
| 15 | - | Surrogates | $13,104 | - | 27 | - | $485 | $226,561 | 7 | Walt Disney Pictures | false | false |
| 16 | 10 | The Princess and the Frog | $10,761 | -34.8% | 40 | - | $269 | $672,567 | 5 | Walt Disney Pictures | false | false |
| 17 | 11 | The Soloist | $3,414 | -53.9% | 5 | - | $682 | $35,363 | 3 | Universal Pictures International (UPI) | false | false |
| 18 | - | Funny People | $2,954 | - | 18 | - | $164 | $147,671 | 8 | Universal Pictures International (UPI) | false | false |
| 19 | - | It's Alive | $515 | - | 18 | - | $28 | $122,656 | 8 | N/A | false | false |
| 20 | 14 | Zombieland | $16 | -86% | 1 | -1 | $16 | $118,653 | 4 | Sony Pictures Releasing | false | false |
