| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $978,644 | +3.6% | 140 | +9 | $6,990 | $8,795,750 | 5 | 20th Century Fox International | false | false |
| 2 | 2 | Sherlock Holmes | $295,045 | -21.7% | 87 | +7 | $3,391 | $1,785,385 | 3 | Warner Bros. | false | false |
| 3 | 3 | Old Dogs | $241,220 | +15.3% | 68 | +3 | $3,547 | $582,575 | 2 | Walt Disney Pictures | false | false |
| 4 | - | Invictus | $227,602 | - | 45 | - | $5,057 | $227,602 | 1 | Warner Bros. | true | false |
| 5 | 5 | Alvin and the Chipmunks: The Squeakquel | $174,536 | -10.6% | 94 | +6 | $1,856 | $501,673 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | Up in the Air | $133,624 | -32.4% | 49 | +1 | $2,727 | $411,601 | 2 | Paramount Pictures International | false | false |
| 7 | 6 | The Princess and the Frog | $119,919 | -5.7% | 103 | +5 | $1,164 | $1,586,570 | 4 | Walt Disney Pictures | false | false |
| 8 | - | Nine | $108,621 | - | 25 | - | $4,344 | $108,621 | 1 | Sony Pictures Releasing | true | false |
| 9 | 7 | It's Complicated | $100,474 | -16.9% | 63 | +6 | $1,594 | $1,034,177 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Daybreakers | $77,829 | -25.1% | 33 | -4 | $2,358 | $228,370 | 2 | Distribution Company | false | false |
| 11 | - | Astro Boy | $49,620 | - | 29 | - | $1,711 | $49,620 | 1 | Alfa Films | true | false |
| 12 | - | Zombieland | $41,097 | - | 20 | - | $2,054 | $41,097 | 1 | Sony Pictures Releasing | true | false |
| 13 | - | Nora's Will | $16,714 | - | 11 | - | $1,519 | $16,714 | 1 | Primer Plano Film Group | true | false |
| 14 | 10 | The Young Victoria | $15,014 | -27.6% | 19 | +2 | $790 | $141,603 | 3 | Distribution Company | false | false |
| 15 | 15 | Ninja Assassin | $10,800 | +196% | 20 | +6 | $540 | $109,077 | 4 | Warner Bros. | false | false |
| 16 | 9 | 2012 | $9,362 | -62.2% | 14 | -21 | $668 | $3,996,008 | 9 | Sony Pictures Releasing | false | false |
| 17 | 12 | Easy Virtue | $6,695 | -48.7% | 9 | -2 | $743 | $88,519 | 3 | Sony Pictures Releasing | false | false |
| 18 | 11 | Paranormal Activity | $6,342 | -53.6% | 13 | -11 | $487 | $1,267,937 | 8 | Distribution Company | false | false |
| 19 | 13 | Jellyfish 2010 Re-release | $5,275 | -24.6% | 5 | - | $1,055 | $15,218 | 2 | N/A | false | false |
| 20 | 16 | Halloween II | $1,812 | -39.2% | 6 | -5 | $302 | $109,736 | 4 | Distribution Company | false | false |
| 21 | 18 | The Secret in Their Eyes | $1,785 | -27.9% | 5 | - | $357 | $9,287,396 | 25 | Distribution Company | false | false |
| 22 | 19 | Let the Right One In | $1,774 | -25.6% | 3 | -1 | $591 | $169,304 | 9 | Pachamama Cine | false | false |
| 23 | 26 | Spread | $1,347 | +362.9% | 2 | +1 | $673 | $120,235 | 5 | Impacto Cine | false | false |
| 24 | 14 | Departures | $1,242 | -67.7% | 5 | - | $248 | $16,124 | 3 | Alfa Films | false | false |
| 25 | 17 | Le code a changé | $1,168 | -58.4% | 3 | -2 | $389 | $134,221 | 5 | Alfa Films | false | false |
| 26 | 20 | 500 Days of Summer | $637 | -64.2% | 3 | -5 | $212 | $360,793 | 11 | 20th Century Fox International | false | false |
| 27 | 31 | Eden Lake | $534 | +662.9% | 1 | - | $534 | $65,011 | 7 | CDI Films | false | false |
| 28 | 29 | Let it Rain | $479 | +252.2% | 2 | -1 | $239 | $140,479 | 8 | Alfa Films | false | false |
| 29 | 22 | Two Lovers | $450 | -50.4% | 3 | -4 | $150 | $397,266 | 11 | Distribution Company | false | false |
| 30 | 24 | Planet 51 | $352 | -16.2% | 2 | -3 | $176 | $722,795 | 10 | CDI Films | false | false |
| 31 | 23 | Whiteout | $249 | -66.7% | 1 | -5 | $249 | $449,725 | 12 | Warner Bros. | false | false |
| 32 | 25 | Acne | $240 | -39.5% | 1 | -1 | $240 | $3,474 | 4 | Primer Plano Film Group | false | false |
| 33 | 21 | The Twilight Saga: New Moon | $232 | -79.6% | 2 | -2 | $116 | $3,333,753 | 11 | Alfa Films | false | false |
| 34 | 30 | Broken Embraces | $205 | +68% | 2 | - | $102 | $525,022 | 18 | Universal Pictures International (UPI) | false | false |
| 35 | 33 | Inglourious Basterds | $190 | +1,087.5% | 1 | - | $190 | $1,236,854 | 22 | Universal Pictures International (UPI) | false | false |
