| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $4,021,650 | -20.4% | 384 | -36 | $10,473 | $81,977,381 | 7 | 20th Century Fox International | false | false |
| 2 | - | Law Abiding Citizen | $1,644,144 | - | 194 | - | $8,474 | $1,660,030 | 1 | Roadshow Films | true | false |
| 3 | 3 | Invictus | $1,133,473 | -28.2% | 262 | +1 | $4,326 | $3,515,441 | 2 | Warner Bros. | false | false |
| 4 | 4 | It's Complicated | $1,089,530 | -25.5% | 274 | -29 | $3,976 | $11,128,496 | 4 | Universal Pictures International (UPI) | false | false |
| 5 | 2 | Tooth Fairy | $1,007,988 | -46.7% | 242 | -1 | $4,165 | $7,979,230 | 3 | 20th Century Fox International | false | false |
| 6 | 7 | Bran Nue Dae | $720,715 | -26% | 234 | +2 | $3,079 | $4,559,637 | 3 | Roadshow Films | false | false |
| 7 | 5 | Up in the Air | $710,363 | -35.4% | 168 | +21 | $4,228 | $4,520,200 | 3 | Paramount Pictures International | false | false |
| 8 | 6 | Sherlock Holmes | $689,712 | -34% | 239 | -32 | $2,885 | $21,734,134 | 6 | Roadshow Films | false | false |
| 9 | 9 | Nine | $443,130 | -36.2% | 132 | -1 | $3,357 | $1,525,118 | 2 | Sony Pictures Releasing | false | false |
| 10 | - | The Road | $429,607 | - | 61 | - | $7,042 | $429,607 | 1 | Icon Film Distribution | true | false |
| 11 | 8 | Alvin and the Chipmunks: The Squeakquel | $399,900 | -54.9% | 233 | -56 | $1,716 | $19,931,829 | 6 | 20th Century Fox International | false | false |
| 12 | 11 | Toy Story 2009 Re-release | $217,281 | -29.6% | 119 | -6 | $1,825 | $743,563 | 2 | Walt Disney Pictures | false | false |
| 13 | 10 | The Princess and the Frog | $216,047 | -52.1% | 159 | -64 | $1,358 | $5,797,933 | 5 | Walt Disney Pictures | false | false |
| 14 | 13 | The Lovely Bones | $135,977 | -50% | 94 | -66 | $1,446 | $5,571,540 | 6 | Paramount Pictures International | false | false |
| 15 | 12 | Old Dogs | $130,828 | -52% | 92 | -73 | $1,422 | $8,383,867 | 6 | Walt Disney Pictures | false | false |
| 16 | 14 | Fantastic Mr. Fox | $128,560 | -44.5% | 103 | -52 | $1,248 | $3,464,345 | 11 | 20th Century Fox International | false | false |
| 17 | 16 | Bright Star | $71,450 | -15.9% | 43 | +1 | $1,661 | $2,294,441 | 6 | Hopscotch Films | false | false |
| 18 | 15 | In the Loop | $69,548 | -22.3% | 25 | +7 | $2,781 | $297,492 | 2 | Madman Entertainment | false | false |
| 19 | - | Precious | $42,764 | - | 25 | - | $1,710 | $42,764 | - | Icon Film Distribution | - | false |
| 20 | 19 | Did You Hear About the Morgans? | $32,490 | -46.4% | 42 | -18 | $773 | $5,471,538 | 6 | Sony Pictures Releasing | false | false |
