| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $472,873 | -11.4% | 85 | -11 | $5,563 | $8,135,114 | 7 | 20th Century Fox International | false | false |
| 2 | - | Alvin and the Chipmunks: The Squeakquel | $319,430 | - | 53 | - | $6,026 | $319,430 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Sherlock Holmes | $212,744 | -32.7% | 65 | +2 | $3,272 | $703,947 | 2 | Warner Bros. | false | false |
| 4 | - | It's Complicated | $64,103 | - | 28 | - | $2,289 | $64,103 | 1 | United International Pictures | true | false |
| 5 | - | Ninja Assassin | $34,734 | - | 23 | - | $1,510 | $34,734 | 1 | Warner Bros. | true | false |
| 6 | 3 | Tooth Fairy | $31,558 | -53.9% | 37 | +1 | $852 | $460,468 | 4 | 20th Century Fox International | false | false |
| 7 | 5 | Saw VI | $31,027 | -41.7% | 25 | -2 | $1,241 | $114,759 | 2 | Walt Disney Pictures | false | false |
| 8 | 4 | Astro Boy | $27,032 | -53.2% | 26 | -1 | $1,039 | $116,538 | 2 | N/A | false | false |
| 9 | - | The Imaginarium of Doctor Parnassus | $22,730 | - | 6 | - | $3,788 | $22,730 | 1 | Sony Pictures Releasing | true | false |
| 10 | - | Two Lovers | $17,900 | - | 8 | - | $2,237 | $17,900 | 1 | N/A | true | false |
| 11 | 7 | Broken Embraces | $12,319 | -49.8% | 7 | -7 | $1,759 | $87,723 | 3 | United International Pictures | false | false |
| 12 | 10 | The Haunting in Connecticut | $10,529 | -34% | 8 | -5 | $1,316 | $78,184 | 3 | Transeuropa | false | false |
| 13 | 6 | The Princess and the Frog | $8,836 | -69.3% | 17 | -9 | $519 | $926,765 | 9 | Walt Disney Pictures | false | false |
| 14 | 9 | Old Dogs | $5,743 | -69.7% | 9 | -9 | $638 | $361,883 | 6 | Walt Disney Pictures | false | false |
| 15 | 12 | An Education | $4,470 | -58.9% | 5 | - | $894 | $20,387 | 2 | Sony Pictures Releasing | false | false |
| 16 | 8 | Paranormal Activity | $3,824 | -82.1% | 9 | -14 | $424 | $676,027 | 6 | N/A | false | false |
| 17 | 11 | Surrogates | $2,585 | -81.4% | 5 | -14 | $517 | $167,422 | 4 | Walt Disney Pictures | false | false |
| 18 | 15 | Planet 51 | $969 | -23.4% | 12 | +1 | $80 | $274,117 | 10 | N/A | false | false |
| 19 | 14 | Cirque du Freak: The Vampire's Assistant | $458 | -84.9% | 2 | -8 | $229 | $85,873 | 4 | United International Pictures | false | false |
| 20 | 13 | Did You Hear About the Morgans? | $128 | -97.8% | 1 | -12 | $128 | $92,848 | 4 | Sony Pictures Releasing | false | false |
| 21 | 16 | 9 | $45 | -95.9% | 1 | -3 | $45 | $102,027 | 5 | N/A | false | false |
| 22 | 17 | The Twilight Saga: New Moon | $45 | -95.8% | 1 | -2 | $45 | $2,478,548 | 10 | N/A | false | false |
