| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $557,237 | -21.8% | 87 | -2 | $6,405 | $9,359,976 | 7 | 20th Century Fox International | false | false |
| 2 | 2 | It's Complicated | $243,768 | -23.9% | 56 | -1 | $4,353 | $716,677 | 2 | United International Pictures | false | false |
| 3 | - | Nine | $133,168 | - | 30 | - | $4,438 | $133,168 | 53 | Sony Pictures Releasing | false | false |
| 4 | - | Invictus | $114,008 | - | 46 | - | $2,478 | $114,008 | 1 | Warner Bros. | true | false |
| 5 | 4 | Sherlock Holmes | $108,314 | -41.2% | 73 | +4 | $1,483 | $2,537,005 | 6 | Roadshow Films | false | false |
| 6 | 5 | Tooth Fairy | $106,779 | -41.3% | 59 | -4 | $1,809 | $707,734 | 3 | 20th Century Fox International | false | false |
| 7 | 3 | Alvin and the Chipmunks: The Squeakquel | $103,517 | -45.5% | 75 | - | $1,380 | $2,606,663 | 6 | 20th Century Fox International | false | false |
| 8 | 6 | The Lovely Bones | $60,691 | -53% | 60 | -1 | $1,011 | $2,258,276 | 6 | Paramount Pictures International | false | false |
| 9 | 7 | Up in the Air | $58,561 | -50.5% | 20 | - | $2,928 | $401,164 | 3 | Paramount Pictures International | false | false |
| 10 | 9 | Fantastic Mr. Fox | $46,475 | -42.1% | 48 | - | $968 | $486,430 | 4 | 20th Century Fox International | false | false |
| 11 | 8 | Paranormal Activity | $46,131 | -52.2% | 46 | -1 | $1,002 | $860,947 | 5 | Icon Film Distribution | false | false |
| 12 | 12 | The Girl with the Dragon Tattoo | $44,872 | -14.4% | 35 | +1 | $1,282 | $498,652 | 7 | Rialto Distribution | false | false |
| 13 | 11 | Astro Boy | $35,992 | -45.7% | 53 | +7 | $679 | $137,383 | 2 | Hoyts Distribution | false | false |
| 14 | 10 | Old Dogs | $29,560 | -55.4% | 40 | -6 | $739 | $495,308 | 4 | Walt Disney Pictures | false | false |
| 15 | 13 | The Princess and the Frog | $25,117 | -49.1% | 45 | -14 | $558 | $557,614 | 5 | Walt Disney Pictures | false | false |
| 16 | 23 | The Time Traveler's Wife | $6,637 | +28.1% | 20 | - | $331 | $603,451 | 9 | Roadshow Films | false | false |
| 17 | - | Broken Embraces | $5,171 | - | 5 | - | $1,034 | $8,168 | 1 | Paramount Pictures International | true | false |
| 18 | 16 | Veer | $4,739 | -45.9% | 2 | -1 | $2,369 | $17,187 | 2 | - | false | false |
| 19 | 21 | The Twilight Saga: New Moon | $4,432 | -33.5% | 13 | -3 | $340 | $4,295,120 | 11 | Hoyts Distribution | false | false |
| 20 | 22 | Noodle | $3,967 | -29.7% | 13 | +2 | $305 | $12,039 | 2 | - | false | false |
| 21 | 20 | Where the Wild Things Are | $3,957 | -46.7% | 20 | -7 | $197 | $887,793 | 9 | Roadshow Films | false | false |
| 22 | 15 | Whip It | $3,813 | -72.5% | 25 | +1 | $152 | $153,404 | 4 | Roadshow Films | false | false |
| 23 | - | I'm Not Harry Jenson. | $3,249 | - | 18 | - | $180 | $3,249 | 1 | Rialto Distribution | true | false |
| 24 | 18 | Julie & Julia | $3,131 | -59.1% | 8 | -2 | $391 | $1,362,120 | 15 | Sony Pictures Releasing | false | false |
| 25 | 17 | Creation | $2,577 | -66.8% | 17 | -5 | $151 | $108,146 | 6 | Icon Film Distribution | false | false |
| 26 | 24 | 3 Idiots | $1,747 | -54.8% | 2 | -2 | $873 | $176,577 | 6 | Mind Blowing Films | false | false |
| 27 | 19 | My Sister's Keeper | $1,411 | -81.1% | 5 | -6 | $282 | $927,945 | 13 | Roadshow Films | false | false |
| 28 | 27 | Planet 51 | $1,210 | -38.8% | 12 | -1 | $100 | $284,976 | 8 | Hoyts Distribution | false | false |
| 29 | - | Rann | $1,146 | - | 1 | - | $1,146 | $1,146 | 1 | - | true | false |
| 30 | 26 | Chance Pe Dance | $751 | -70.2% | 1 | -1 | $751 | $10,104 | 3 | Mind Blowing Films | false | false |
| 31 | 31 | Cold Souls | $583 | -56.5% | 2 | - | $291 | $6,256 | 3 | Madman Entertainment | false | false |
| 32 | 35 | Amelia | $582 | -28% | 5 | +2 | $116 | $123,193 | 8 | 20th Century Fox International | false | false |
| 33 | 32 | Departures | $577 | -53.5% | 3 | -3 | $192 | $196,441 | 24 | Madman Entertainment | false | false |
| 34 | - | Under the Mountain | $572 | - | 6 | - | $95 | $195,164 | 8 | Walt Disney Pictures | false | false |
| 35 | 28 | Five Minutes of Heaven | $542 | -71% | 3 | -3 | $180 | $30,721 | 7 | Madman Entertainment | false | false |
| 36 | 37 | The Imaginarium of Doctor Parnassus | $318 | -43.7% | 2 | - | $159 | $248,878 | 13 | Hoyts Distribution | false | false |
| 37 | 30 | Whatever Works | $169 | -87.8% | 1 | -6 | $169 | $19,291 | 4 | Hopscotch Films | false | false |
| 38 | 38 | Mary and Max | $168 | -63.5% | 3 | - | $56 | $53,162 | 10 | Icon Film Distribution | false | false |
| 39 | 36 | Valentino: The Last Emperor | $157 | -79.3% | 1 | -1 | $157 | $70,564 | 10 | Hopscotch Films | false | false |
| 40 | 34 | Looking for Eric | $155 | -81.2% | 2 | -2 | $77 | $115,856 | 10 | Icon Film Distribution | false | false |
| 41 | 39 | Bandslam | $58 | -86.6% | 1 | -2 | $58 | $82,977 | 7 | Hoyts Distribution | false | false |
| 42 | - | Tyson | $31 | - | 1 | - | $31 | $22,871 | 15 | Hopscotch Films | false | false |
| 43 | 41 | A Heavenly Vintage | $19 | -64.2% | 1 | -1 | $19 | $135,128 | 12 | Icon Film Distribution | false | false |
