| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $3,420,651 | -14.9% | 368 | -16 | $9,295 | $85,480,399 | 8 | 20th Century Fox International | false | false |
| 2 | - | Edge of Darkness | $1,245,913 | - | 205 | - | $6,077 | $1,245,913 | 1 | Icon Film Distribution | true | false |
| 3 | - | Daybreakers | $924,754 | - | 135 | - | $6,850 | $924,754 | 1 | Hoyts Distribution | true | false |
| 4 | 2 | Law Abiding Citizen | $900,877 | -45.2% | 193 | -1 | $4,667 | $3,052,459 | 2 | Roadshow Films | false | false |
| 5 | 3 | Invictus | $827,302 | -27% | 261 | -1 | $3,169 | $4,693,420 | 3 | Warner Bros. | false | false |
| 6 | 4 | It's Complicated | $799,291 | -26.6% | 270 | -4 | $2,960 | $12,196,140 | 5 | Universal Pictures International (UPI) | false | false |
| 7 | 7 | Up in the Air | $718,475 | +1.1% | 191 | +23 | $3,761 | $5,440,894 | 4 | Paramount Pictures International | false | false |
| 8 | 5 | Tooth Fairy | $520,008 | -48.4% | 215 | -27 | $2,418 | $8,503,064 | 4 | 20th Century Fox International | false | false |
| 9 | 6 | Bran Nue Dae | $491,909 | -31.7% | 232 | -2 | $2,120 | $5,219,999 | 4 | Roadshow Films | false | false |
| 10 | 8 | Sherlock Holmes | $415,981 | -39.7% | 200 | -39 | $2,079 | $21,962,925 | 7 | Roadshow Films | false | false |
| 11 | 10 | The Road | $277,562 | -35.4% | 62 | +1 | $4,476 | $862,625 | 2 | Icon Film Distribution | false | false |
| 12 | 9 | Nine | $254,092 | -42.7% | 125 | -7 | $2,032 | $1,946,841 | 3 | Sony Pictures Releasing | false | false |
| 13 | - | Precious | $216,512 | - | 27 | - | $8,018 | $258,535 | 1 | Icon Film Distribution | true | false |
| 14 | 11 | Alvin and the Chipmunks: The Squeakquel | $146,247 | -63.4% | 185 | -48 | $790 | $19,791,144 | 7 | 20th Century Fox International | false | false |
| 15 | 12 | Toy Story 2009 Re-release | $101,734 | -53.2% | 61 | -58 | $1,667 | $871,836 | 3 | Walt Disney Pictures | false | false |
| 16 | 17 | Bright Star | $74,541 | +4.3% | 53 | +10 | $1,406 | $2,369,022 | 7 | Hopscotch Films | false | false |
| 17 | 13 | The Princess and the Frog | $73,801 | -65.8% | 84 | -75 | $878 | $5,830,322 | 6 | Walt Disney Pictures | false | false |
| 18 | 16 | Fantastic Mr. Fox | $69,635 | -45.8% | 69 | -34 | $1,009 | $3,494,007 | 12 | 20th Century Fox International | false | false |
| 19 | 14 | The Lovely Bones | $69,056 | -49.2% | 65 | -29 | $1,062 | $5,597,671 | 7 | Paramount Pictures International | false | false |
| 20 | 18 | In the Loop | $58,146 | -16.4% | 25 | - | $2,325 | $382,300 | 3 | Madman Entertainment | false | false |
