| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $413,184 | -12.6% | 77 | -8 | $5,366 | $8,534,984 | 8 | 20th Century Fox International | false | false |
| 2 | 2 | Alvin and the Chipmunks: The Squeakquel | $199,358 | -37.6% | 54 | +1 | $3,691 | $695,504 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Sherlock Holmes | $143,001 | -32.8% | 61 | -4 | $2,344 | $940,498 | 3 | Warner Bros. | false | false |
| 4 | - | Invictus | $62,467 | - | 19 | - | $3,287 | $62,467 | 1 | Warner Bros. | true | false |
| 5 | - | Up in the Air | $44,987 | - | 21 | - | $2,142 | $44,987 | 1 | United International Pictures | true | false |
| 6 | 4 | It's Complicated | $44,068 | -31.3% | 29 | +1 | $1,519 | $143,148 | 2 | United International Pictures | false | false |
| 7 | 6 | Tooth Fairy | $23,767 | -24.7% | 25 | -12 | $950 | $490,267 | 5 | 20th Century Fox International | false | false |
| 8 | 8 | Astro Boy | $19,466 | -28% | 23 | -3 | $846 | $147,514 | 3 | N/A | false | false |
| 9 | 5 | Ninja Assassin | $17,044 | -50.9% | 23 | - | $741 | $74,267 | 2 | Warner Bros. | false | false |
| 10 | 7 | Saw VI | $15,791 | -49.1% | 18 | -7 | $877 | $148,151 | 3 | Walt Disney Pictures | false | false |
| 11 | 9 | The Imaginarium of Doctor Parnassus | $15,081 | -33.7% | 6 | - | $2,513 | $50,338 | 2 | Sony Pictures Releasing | false | false |
| 12 | 12 | The Haunting in Connecticut | $13,947 | +32.5% | 10 | +2 | $1,394 | $96,033 | 4 | Transeuropa | false | false |
| 13 | 10 | Two Lovers | $11,539 | -35.5% | 9 | +1 | $1,282 | $38,821 | 2 | N/A | false | false |
| 14 | - | Traitor | $7,386 | - | 10 | - | $738 | $7,386 | 1 | N/A | true | false |
| 15 | 11 | Broken Embraces | $7,126 | -42.2% | 3 | -4 | $2,375 | $97,508 | 4 | United International Pictures | false | false |
| 16 | 13 | The Princess and the Frog | $3,486 | -60.5% | 7 | -10 | $498 | $900,644 | 10 | Walt Disney Pictures | false | false |
| 17 | 14 | Old Dogs | $2,766 | -51.8% | 7 | -2 | $395 | $354,398 | 7 | Walt Disney Pictures | false | false |
| 18 | 15 | An Education | $2,657 | -40.6% | 3 | -2 | $885 | $24,919 | 3 | Sony Pictures Releasing | false | false |
| 19 | 16 | Paranormal Activity | $950 | -75.2% | 4 | -5 | $237 | $654,695 | 7 | N/A | false | false |
| 20 | 18 | Planet 51 | $807 | -16.7% | 10 | -2 | $80 | $265,013 | 11 | N/A | false | false |
| 21 | 17 | Surrogates | $398 | -84.6% | 1 | -4 | $398 | $162,762 | 5 | Walt Disney Pictures | false | false |
| 22 | 19 | Cirque du Freak: The Vampire's Assistant | $184 | -59.8% | 1 | -1 | $184 | $83,300 | 5 | United International Pictures | false | false |
