| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up in the Air | $491,491 | - | 43 | - | $11,430 | $491,491 | 1 | United International Pictures | true | false |
| 2 | 2 | Avatar | $335,383 | -25.4% | 26 | -2 | $12,899 | $9,940,068 | 8 | 20th Century Fox International | false | false |
| 3 | 3 | Cloudy with a Chance of Meatballs | $319,577 | -25.9% | 77 | -1 | $4,150 | $780,701 | 2 | Sony Pictures Releasing | false | false |
| 4 | 1 | I Love Karditsa | $307,023 | -49.2% | 56 | -6 | $5,482 | $3,608,272 | 4 | Odeon | false | false |
| 5 | - | Dangerous Cooking | $275,335 | - | 75 | - | $3,671 | $275,335 | 1 | Odeon | true | false |
| 6 | 4 | Sherlock Holmes | $179,008 | -53.6% | 56 | -9 | $3,196 | $2,775,298 | 4 | Roadshow Films | false | false |
| 7 | 7 | Agora | $105,827 | -44.6% | 23 | -1 | $4,601 | $378,959 | 2 | Odeon | false | false |
| 8 | 6 | The Island | $101,117 | -50% | 29 | -16 | $3,486 | $5,696,912 | 6 | Roadshow Films | false | false |
| 9 | 5 | Invictus | $81,896 | -60% | 39 | -3 | $2,099 | $343,660 | 2 | Warner Bros. | false | false |
| 10 | 8 | Dorian Gray | $44,523 | -54.4% | 15 | -1 | $2,968 | $188,325 | 2 | Odeon | false | false |
| 11 | 11 | Did You Hear About the Morgans? | $18,055 | -49% | 9 | -7 | $2,006 | $776,304 | 5 | Sony Pictures Releasing | false | false |
