| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $366,567 | -34.2% | 75 | -12 | $4,887 | $9,882,303 | 8 | 20th Century Fox International | false | false |
| 2 | 2 | It's Complicated | $143,437 | -41.2% | 58 | +2 | $2,473 | $988,781 | 3 | United International Pictures | false | false |
| 3 | - | Did You Hear About the Morgans? | $105,370 | - | 57 | - | $1,848 | $105,370 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | Precious | $84,107 | - | 30 | - | $2,803 | $84,107 | 1 | Icon Film Distribution | true | false |
| 5 | - | Edge of Darkness | $81,784 | - | 45 | - | $1,817 | $81,784 | 1 | Icon Film Distribution | true | false |
| 6 | 3 | Nine | $68,253 | -48.7% | 30 | - | $2,275 | $277,042 | 54 | Sony Pictures Releasing | false | false |
| 7 | 4 | Invictus | $52,426 | -54% | 46 | - | $1,139 | $226,460 | 2 | Warner Bros. | false | false |
| 8 | 5 | Sherlock Holmes | $45,379 | -58.1% | 62 | -11 | $731 | $2,568,597 | 7 | Roadshow Films | false | false |
| 9 | 9 | Up in the Air | $42,709 | -27.1% | 30 | +10 | $1,423 | $467,980 | 4 | Paramount Pictures International | false | false |
| 10 | 8 | The Lovely Bones | $27,267 | -55.1% | 52 | -8 | $524 | $2,286,130 | 7 | Paramount Pictures International | false | false |
| 11 | 12 | The Girl with the Dragon Tattoo | $25,482 | -43.2% | 35 | - | $728 | $522,561 | 8 | Rialto Distribution | false | false |
| 12 | - | R. Strauss: Der Rosenkavalier | $23,792 | - | 14 | - | $1,699 | $23,792 | 1 | Rialto Distribution | true | false |
| 13 | 6 | Tooth Fairy | $21,145 | -80.2% | 58 | -1 | $364 | $778,638 | 4 | 20th Century Fox International | false | false |
| 14 | 7 | Alvin and the Chipmunks: The Squeakquel | $19,251 | -81.4% | 61 | -14 | $315 | $2,634,177 | 7 | 20th Century Fox International | false | false |
| 15 | 11 | Paranormal Activity | $13,694 | -70.3% | 31 | -15 | $441 | $883,860 | 6 | Icon Film Distribution | false | false |
| 16 | 10 | Fantastic Mr. Fox | $12,835 | -72.4% | 37 | -11 | $346 | $520,256 | 5 | 20th Century Fox International | false | false |
| 17 | 13 | Astro Boy | $7,193 | -80% | 41 | -12 | $175 | $163,403 | 3 | Hoyts Distribution | false | false |
| 18 | 15 | The Princess and the Frog | $6,963 | -72.3% | 30 | -15 | $232 | $573,149 | 6 | Walt Disney Pictures | false | false |
| 19 | 14 | Old Dogs | $6,124 | -79.3% | 28 | -12 | $218 | $511,469 | 5 | Walt Disney Pictures | false | false |
| 20 | - | Charlie & Boots | $4,859 | - | 17 | - | $285 | $4,859 | 1 | Paramount Pictures International | true | false |
| 21 | 16 | The Time Traveler's Wife | $3,963 | -40.3% | 24 | +4 | $165 | $600,530 | 10 | Roadshow Films | false | false |
| 22 | 17 | Broken Embraces | $3,878 | -25% | 6 | +1 | $646 | $15,201 | 2 | Paramount Pictures International | false | false |
| 23 | - | Mid-August Lunch | $3,598 | - | 11 | - | $327 | $95,823 | 5 | Rialto Distribution | false | false |
| 24 | 24 | Julie & Julia | $2,185 | -30.2% | 6 | -2 | $364 | $1,344,538 | 16 | Sony Pictures Releasing | false | false |
| 25 | 19 | The Twilight Saga: New Moon | $1,707 | -61.5% | 8 | -5 | $213 | $4,228,442 | 12 | Hoyts Distribution | false | false |
| 26 | 21 | Where the Wild Things Are | $1,501 | -62.1% | 18 | -2 | $83 | $880,736 | 10 | Roadshow Films | false | false |
| 27 | 23 | I'm Not Harry Jenson. | $915 | -71.8% | 18 | - | $50 | $6,196 | 2 | Rialto Distribution | false | false |
| 28 | 25 | Creation | $896 | -65.2% | 14 | -3 | $64 | $109,569 | 7 | Icon Film Distribution | false | false |
| 29 | 22 | Whip It | $877 | -77% | 10 | -15 | $87 | $152,440 | 5 | Roadshow Films | false | false |
| 30 | 27 | My Sister's Keeper | $769 | -45.5% | 6 | +1 | $128 | $919,142 | 14 | Roadshow Films | false | false |
| 31 | 18 | Veer | $609 | -87.1% | 1 | -1 | $609 | $18,997 | 3 | - | false | false |
| 32 | 33 | Departures | $522 | -9.5% | 3 | - | $174 | $194,057 | 25 | Madman Entertainment | false | false |
| 33 | 40 | Looking for Eric | $441 | +184.5% | 5 | +3 | $88 | $114,528 | 11 | Icon Film Distribution | false | false |
| 34 | 35 | Five Minutes of Heaven | $430 | -20.7% | 4 | +1 | $107 | $30,976 | 8 | Madman Entertainment | false | false |
| 35 | 28 | Planet 51 | $207 | -82.9% | 7 | -5 | $29 | $281,909 | 9 | Hoyts Distribution | false | false |
| 36 | 34 | Under the Mountain | $160 | -72% | 4 | -2 | $40 | $192,258 | 9 | Walt Disney Pictures | false | false |
| 37 | - | Is Anybody There? | $136 | - | 1 | - | $136 | $116,278 | 22 | Hopscotch Films | false | false |
| 38 | 36 | The Imaginarium of Doctor Parnassus | $98 | -69.2% | 2 | - | $49 | $245,282 | 14 | Hoyts Distribution | false | false |
| 39 | 38 | Mary and Max | $72 | -57.1% | 3 | - | $24 | $52,422 | 11 | Icon Film Distribution | false | false |
