| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $67,513 | +45.5% | 9 | +2 | $7,501 | $831,524 | 8 | 20th Century Fox International | false | false |
| 2 | 2 | Invictus | $29,145 | +28.2% | 8 | - | $3,643 | $119,907 | 3 | Warner Bros. | false | false |
| 3 | - | Toy Story 2009 Re-release | $23,619 | - | 6 | - | $3,936 | $23,619 | 1 | Walt Disney Pictures | true | false |
| 4 | 4 | Old Dogs | $23,527 | +51.3% | 5 | - | $4,705 | $85,651 | 3 | Walt Disney Pictures | false | false |
| 5 | 3 | Sherlock Holmes | $18,186 | +16.1% | 7 | - | $2,598 | $165,313 | 4 | Warner Bros. | false | false |
| 6 | 8 | Alvin and the Chipmunks: The Squeakquel | $14,312 | +86.6% | 5 | - | $2,862 | $140,312 | 6 | 20th Century Fox International | false | false |
| 7 | - | The Hurt Locker | $14,034 | - | 4 | - | $3,508 | $14,034 | 1 | N/A | true | false |
| 8 | 5 | It's Complicated | $13,976 | +3.8% | 4 | -3 | $3,494 | $137,687 | 4 | United International Pictures | false | false |
| 9 | 6 | Up in the Air | $13,113 | +46.1% | 3 | -5 | $4,371 | $105,681 | 3 | Paramount Pictures International | false | false |
| 10 | 10 | Astro Boy | $7,582 | +23.2% | 4 | - | $1,895 | $20,534 | 2 | N/A | false | false |
| 11 | 9 | The Girl with the Dragon Tattoo | $6,708 | -8.1% | 4 | - | $1,677 | $53,456 | 3 | N/A | false | false |
| 12 | 7 | Easy Virtue | $6,587 | -14.6% | 4 | - | $1,646 | $19,615 | 2 | Sony Pictures Releasing | false | false |
| 13 | 11 | The Princess and the Frog | $4,050 | +11.4% | 4 | -1 | $1,012 | $70,470 | 5 | Walt Disney Pictures | false | false |
| 14 | 12 | Funny People | $3,422 | +19.7% | 1 | -1 | $3,422 | $7,572 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | - | Ninja Assassin | $2,349 | - | 3 | - | $783 | $2,730 | 1 | Warner Bros. | true | false |
| 16 | 14 | The Young Victoria | $1,912 | -18.4% | 2 | -1 | $956 | $33,515 | 4 | N/A | false | false |
| 17 | 13 | Paranormal Activity | $1,779 | -24.9% | 2 | - | $889 | $56,039 | 6 | N/A | false | false |
| 18 | 16 | Zombieland | $883 | +11.6% | 1 | - | $883 | $23,931 | 5 | Sony Pictures Releasing | false | false |
| 19 | 15 | My Stars | $727 | -54.9% | 1 | -2 | $727 | $3,114 | 2 | N/A | false | false |
| 20 | 19 | Emma's Bliss | $316 | +9% | 1 | - | $316 | $775 | 2 | N/A | false | false |
| 21 | 20 | All About Steve | $185 | -33.5% | 1 | - | $185 | $53,139 | 5 | 20th Century Fox International | false | false |
