| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $425,014 | -2.8% | 94 | - | $4,521 | $5,537,971 | 7 | 20th Century Fox International | false | false |
| 2 | - | The Princess and the Frog | $307,174 | - | 74 | - | $4,151 | $307,174 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Did You Hear About the Morgans? | $165,989 | -31.8% | 61 | - | $2,721 | $506,462 | 2 | N/A | false | false |
| 4 | - | Ninja Assassin | $87,287 | - | 40 | - | $2,182 | $87,287 | 1 | N/A | true | false |
| 5 | - | Up in the Air | $87,121 | - | 26 | - | $3,350 | $87,121 | 1 | United International Pictures | true | false |
| 6 | 3 | Sherlock Holmes | $84,064 | -25.4% | 63 | -4 | $1,334 | $1,375,322 | 5 | N/A | false | false |
| 7 | 4 | Couples Retreat | $65,708 | -16.3% | 56 | -4 | $1,173 | $1,894,892 | 8 | N/A | false | false |
| 8 | 6 | Alvin and the Chipmunks: The Squeakquel | $45,590 | -33.6% | 57 | -12 | $799 | $1,728,591 | 6 | N/A | false | false |
| 9 | 5 | Planet 51 | $39,405 | -45.8% | 45 | -8 | $875 | $570,472 | 4 | N/A | false | false |
| 10 | 7 | The Rebound | $32,959 | -29% | 35 | -3 | $941 | $611,443 | 5 | N/A | false | false |
| 11 | - | All About Steve | $27,434 | - | 10 | - | $2,743 | $27,434 | 1 | N/A | true | false |
| 12 | 8 | Invictus | $25,134 | -41.4% | 29 | -15 | $866 | $1,421,752 | 8 | N/A | false | false |
| 13 | 10 | 2012 | $22,326 | -38.8% | 27 | -9 | $826 | $2,307,675 | 9 | N/A | false | false |
| 14 | 9 | Brothers | $21,296 | -42.1% | 21 | - | $1,014 | $158,833 | 3 | N/A | false | false |
| 15 | 11 | Skin | $19,695 | -23% | 11 | - | $1,790 | $57,822 | 2 | N/A | false | false |
| 16 | - | An Education | $19,163 | - | 11 | - | $1,742 | $19,163 | 1 | United International Pictures | true | false |
| 17 | 12 | A Perfect Getaway | $12,579 | -50.4% | 18 | -7 | $698 | $175,076 | 4 | N/A | false | false |
| 18 | 16 | Julie & Julia | $9,718 | -31.2% | 10 | -1 | $971 | $488,332 | 12 | N/A | false | false |
| 19 | 14 | Old Dogs | $9,277 | -41.3% | 12 | -7 | $773 | $1,470,435 | 10 | N/A | false | false |
| 20 | 18 | The September Issue | $2,419 | -47.8% | 3 | -1 | $806 | $36,746 | 4 | N/A | false | false |
| 21 | - | Bandslam | $190 | - | 1 | - | $190 | $263,946 | 9 | N/A | false | false |
