| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Valentine's Day | $6,676,176 | - | 373 | - | $17,898 | $6,676,176 | 1 | Warner Bros. | true | false |
| 2 | 1 | Avatar | $2,531,683 | -26% | 284 | -84 | $8,914 | $91,143,705 | 9 | 20th Century Fox International | false | false |
| 3 | - | The Wolfman | $1,659,377 | - | 245 | - | $6,772 | $1,659,377 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | Percy Jackson & the Olympians: The Lightning Thief | $1,456,375 | - | 229 | - | $6,359 | $1,456,375 | 1 | 20th Century Fox International | true | false |
| 5 | 2 | Edge of Darkness | $647,688 | -48% | 202 | -3 | $3,206 | $2,364,410 | 2 | Icon Film Distribution | false | false |
| 6 | 5 | Invictus | $441,547 | -46.6% | 224 | -37 | $1,971 | $5,522,666 | 4 | Warner Bros. | false | false |
| 7 | 7 | Up in the Air | $431,468 | -39.9% | 158 | -33 | $2,730 | $6,238,813 | 5 | Paramount Pictures International | false | false |
| 8 | 4 | Law Abiding Citizen | $425,362 | -52.8% | 178 | -15 | $2,389 | $3,812,836 | 3 | Roadshow Films | false | false |
| 9 | 3 | Daybreakers | $415,966 | -55% | 134 | -1 | $3,104 | $1,661,133 | 2 | Hoyts Distribution | false | false |
| 10 | - | My Name Is Khan | $388,758 | - | 37 | - | $10,506 | $388,758 | 1 | 20th Century Fox International | true | false |
| 11 | 6 | It's Complicated | $368,768 | -53.9% | 207 | -63 | $1,781 | $13,153,179 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 9 | Bran Nue Dae | $230,601 | -53.1% | 175 | -57 | $1,317 | $5,831,750 | 5 | Roadshow Films | false | false |
| 13 | 8 | Tooth Fairy | $223,714 | -57% | 169 | -46 | $1,323 | $8,989,566 | 5 | 20th Century Fox International | false | false |
| 14 | 13 | Precious | $166,788 | -23% | 28 | +1 | $5,956 | $520,117 | 2 | Icon Film Distribution | false | false |
| 15 | 11 | The Road | $150,491 | -45.8% | 66 | +4 | $2,280 | $1,135,520 | 3 | Icon Film Distribution | false | false |
| 16 | 10 | Sherlock Holmes | $140,811 | -66.1% | 120 | -80 | $1,173 | $22,777,578 | 8 | Roadshow Films | false | false |
| 17 | 12 | Nine | $69,653 | -72.6% | 65 | -60 | $1,071 | $2,164,990 | 4 | Sony Pictures Releasing | false | false |
| 18 | - | The Hurt Locker | $67,230 | - | 47 | - | $1,430 | $77,972 | - | Roadshow Films | - | false |
| 19 | 16 | Bright Star | $48,814 | -34.5% | 44 | -9 | $1,109 | $2,568,097 | 8 | Hopscotch Films | false | false |
| 20 | - | A Prophet | $45,909 | - | 11 | - | $4,173 | $49,865 | 1 | Sony Pictures Releasing | true | false |
