| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $316,342 | -23.4% | 58 | -19 | $5,454 | $9,097,948 | 9 | 20th Century Fox International | false | false |
| 2 | - | The Wolfman | $196,526 | - | 44 | - | $4,466 | $196,526 | 1 | United International Pictures | true | false |
| 3 | - | Percy Jackson & the Olympians: The Lightning Thief | $157,525 | - | 46 | - | $3,424 | $157,525 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Alvin and the Chipmunks: The Squeakquel | $120,122 | -39.7% | 54 | - | $2,224 | $937,607 | 3 | 20th Century Fox International | false | false |
| 5 | - | Valentine's Day | $112,528 | - | 32 | - | $3,516 | $112,528 | 1 | Warner Bros. | true | false |
| 6 | 3 | Sherlock Holmes | $75,954 | -46.9% | 46 | -15 | $1,651 | $1,095,735 | 4 | Warner Bros. | false | false |
| 7 | 4 | Invictus | $36,750 | -41.2% | 20 | +1 | $1,837 | $127,345 | 2 | Warner Bros. | false | false |
| 8 | 5 | Up in the Air | $27,880 | -38% | 19 | -2 | $1,467 | $94,604 | 2 | United International Pictures | false | false |
| 9 | 6 | It's Complicated | $23,213 | -47.3% | 14 | -15 | $1,658 | $188,941 | 3 | United International Pictures | false | false |
| 10 | 12 | The Haunting in Connecticut | $10,761 | -22.8% | 8 | -2 | $1,345 | $115,142 | 5 | Transeuropa | false | false |
| 11 | 8 | Astro Boy | $9,089 | -53.3% | 14 | -9 | $649 | $168,177 | 4 | N/A | false | false |
| 12 | - | Igor | $8,710 | - | 14 | - | $622 | $8,710 | 1 | N/A | true | false |
| 13 | 11 | The Imaginarium of Doctor Parnassus | $6,777 | -55.1% | 3 | -3 | $2,259 | $65,793 | 3 | Sony Pictures Releasing | false | false |
| 14 | 7 | Tooth Fairy | $5,635 | -76.3% | 9 | -16 | $626 | $512,473 | 6 | 20th Century Fox International | false | false |
| 15 | 10 | Saw VI | $4,905 | -68.9% | 9 | -9 | $545 | $162,992 | 4 | Walt Disney Pictures | false | false |
| 16 | 13 | Two Lovers | $4,223 | -63.4% | 2 | -7 | $2,111 | $48,679 | 3 | N/A | false | false |
| 17 | 15 | Broken Embraces | $1,981 | -72.2% | 1 | -2 | $1,981 | $102,541 | 5 | United International Pictures | false | false |
| 18 | 9 | Ninja Assassin | $1,956 | -88.5% | 5 | -18 | $391 | $87,043 | 3 | Warner Bros. | false | false |
| 19 | 20 | Planet 51 | $984 | +21.9% | 11 | +1 | $89 | $266,555 | 12 | N/A | false | false |
| 20 | 16 | The Princess and the Frog | $551 | -84.2% | 1 | -6 | $551 | $903,340 | 11 | Walt Disney Pictures | false | false |
| 21 | - | Deception | $387 | - | 1 | - | $387 | $13,500 | 48 | Bazuca Films | false | false |
| 22 | 17 | Old Dogs | $340 | -87.7% | 1 | -6 | $340 | $356,742 | 8 | Walt Disney Pictures | false | false |
