| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Avatar | $4,867,114 | -16.5% | 580 | -79 | $8,391 | $142,782,079 | 9 | 20th Century Fox International | false | false |
| 2 | 3 | The Princess and the Frog | $4,462,976 | -15.9% | 697 | +23 | $6,403 | $18,883,165 | 3 | Walt Disney Pictures | false | false |
| 3 | 1 | Sherlock Holmes | $3,783,594 | -35.8% | 670 | -6 | $5,647 | $10,850,678 | 2 | Warner Bros. | false | false |
| 4 | - | Percy Jackson & the Olympians: The Lightning Thief | $3,391,244 | - | 532 | - | $6,374 | $3,391,244 | 1 | 20th Century Fox International | true | false |
| 5 | 4 | Oceans | $2,998,621 | -26.5% | 578 | +27 | $5,187 | $15,299,010 | 3 | N/A | false | false |
| 6 | 5 | Invictus | $1,782,442 | -26.8% | 486 | -9 | $3,667 | $22,728,245 | 5 | Warner Bros. | false | false |
| 7 | - | The Wolfman | $1,565,400 | - | 371 | - | $4,219 | $1,565,400 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 6 | Planet 51 | $1,412,739 | -13.1% | 469 | +15 | $3,012 | $3,453,027 | 2 | N/A | false | false |
| 9 | - | I Love You Phillip Morris | $1,291,400 | - | 198 | - | $6,522 | $1,291,400 | 1 | Europa Filmes | true | false |
| 10 | - | The Lovely Bones | $1,260,051 | - | 301 | - | $4,186 | $1,260,051 | 1 | Paramount Pictures International | true | false |
| 11 | 17 | Protéger & servir | $1,036,805 | +531.6% | 341 | -4 | $3,040 | $3,115,016 | 2 | N/A | false | false |
| 12 | - | Dumas | $871,657 | - | 281 | - | $3,101 | $871,657 | 1 | UGC Distribution | true | false |
| 13 | 7 | Up in the Air | $786,476 | -48.1% | 251 | -61 | $3,133 | $5,699,519 | 3 | Paramount Pictures International | false | false |
| 14 | 9 | Brothers | $671,620 | -38.6% | 184 | -2 | $3,650 | $2,040,632 | 2 | Wild Bunch Distribution | false | false |
| 15 | 8 | Gainsbourg: A Heroic Life | $515,999 | -57.2% | 364 | -119 | $1,417 | $9,234,225 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 11 | A Serious Man | $387,496 | -33.2% | 152 | -5 | $2,549 | $3,582,435 | 4 | StudioCanal | false | false |
| 17 | 10 | An Ordinary Execution | $381,610 | -43.8% | 157 | - | $2,430 | $1,237,785 | 2 | StudioCanal | false | false |
| 18 | - | Horse | $342,303 | - | 119 | - | $2,876 | $342,303 | 1 | N/A | true | false |
| 19 | - | Ninja Assassin | $302,269 | - | 100 | - | $3,022 | $302,269 | 1 | StudioCanal | true | false |
| 20 | 12 | The Book of Eli | $127,243 | -75.4% | 114 | -158 | $1,116 | $4,653,432 | 4 | Metropolitan Filmexport | false | false |
| 21 | 13 | Did You Hear About the Morgans? | $47,340 | -87.1% | 62 | -145 | $763 | $3,965,081 | 4 | Sony Pictures Releasing | false | false |
