| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $5,181,248 | -33.4% | 550 | -125 | $9,420 | $73,958,869 | 5 | 20th Century Fox International | false | false |
| 2 | - | Sorry If I Want to Marry You | $4,011,433 | - | 492 | - | $8,153 | $4,011,433 | 1 | Medusa Distribuzione | true | false |
| 3 | 2 | Paranormal Activity | $1,413,717 | -71.8% | 400 | -11 | $3,534 | $8,039,396 | 2 | Filmauro | false | false |
| 4 | 3 | Kiss Me Again | $1,192,986 | -59.3% | 376 | -208 | $3,172 | $11,285,461 | 3 | Medusa Distribuzione | false | false |
| 5 | - | The Lovely Bones | $1,154,032 | - | 332 | - | $3,476 | $1,154,032 | 1 | United International Pictures | true | false |
| 6 | 4 | Alvin and the Chipmunks: The Squeakquel | $979,805 | -49.4% | 316 | -28 | $3,100 | $6,559,339 | 3 | 20th Century Fox International | false | false |
| 7 | 5 | Up in the Air | $688,721 | -42.2% | 189 | -87 | $3,644 | $6,844,240 | 4 | United International Pictures | false | false |
| 8 | 7 | The Concert | $660,161 | +6.6% | 139 | +1 | $4,749 | $1,583,146 | 2 | BIM Distribuzione | false | false |
| 9 | 6 | The First Beautiful Thing | $437,574 | -42.2% | 126 | -69 | $3,472 | $7,932,912 | 5 | Medusa Distribuzione | false | false |
| 10 | - | Lilly the Witch: The Dragon and the Magic Book | $404,781 | - | 155 | - | $2,611 | $404,781 | 1 | Walt Disney Pictures | true | false |
| 11 | - | Lourdes | $162,133 | - | 83 | - | $1,953 | $178,894 | 1 | N/A | true | false |
| 12 | 11 | The Man Who Will Come | $149,541 | -23.7% | 53 | -13 | $2,821 | $1,128,297 | 4 | Mikado Film | false | false |
| 13 | 8 | Bangkok Dangerous | $102,348 | -72.5% | 57 | -81 | $1,795 | $1,340,173 | 3 | Eagle Pictures | false | false |
| 14 | 9 | Me, Them and Lara | $101,915 | -72% | 44 | -97 | $2,316 | $21,387,497 | 6 | Warner Bros. | false | false |
| 15 | 13 | An Education | $101,707 | -11.9% | 37 | - | $2,748 | $272,702 | 2 | Sony Pictures Releasing | false | false |
| 16 | 12 | A Single Man | $86,822 | -31.5% | 35 | -14 | $2,480 | $1,306,332 | 5 | N/A | false | false |
| 17 | 14 | Soul Kitchen | $86,158 | -22.9% | 29 | -17 | $2,970 | $2,091,656 | 6 | BIM Distribuzione | false | false |
| 18 | 10 | The Fourth Kind | $57,553 | -78.8% | 33 | -62 | $1,744 | $2,333,928 | 4 | Warner Bros. | false | false |
| 19 | 18 | The Hedgehog | $28,316 | -51.9% | 14 | -17 | $2,022 | $3,125,212 | 6 | Eagle Pictures | false | false |
| 20 | 15 | Sherlock Holmes | $27,430 | -74.1% | 10 | -26 | $2,743 | $26,955,437 | 8 | Warner Bros. | false | false |
| 21 | 16 | Pet Pals: Marco Polo's Code | $21,037 | -79.7% | 50 | -57 | $420 | $962,228 | 4 | 01 Distribution | false | false |
| 22 | 17 | Nine | $9,962 | -87.8% | 10 | -47 | $996 | $1,604,773 | 4 | 01 Distribution | false | false |
| 23 | 19 | Cloudy with a Chance of Meatballs | $9,676 | -50.8% | 38 | -12 | $254 | $8,227,101 | 8 | Sony Pictures Releasing | false | false |
| 24 | 23 | A Serious Man | $8,680 | -16.2% | 5 | -1 | $1,736 | $3,644,266 | 11 | Medusa Distribuzione | false | false |
| 25 | 20 | Hachi: A Dog's Tale | $6,075 | -63.7% | 7 | -12 | $867 | $7,465,403 | 7 | Lucky Red | false | false |
| 26 | 21 | The Princess and the Frog | $5,975 | -63.1% | 11 | -15 | $543 | $13,157,233 | 9 | Walt Disney Pictures | false | false |
| 27 | - | Looking for Eric | $4,383 | - | 3 | - | $1,461 | $2,330,354 | 11 | BIM Distribuzione | false | false |
| 28 | 22 | Welcome | $2,602 | -77% | 3 | -12 | $867 | $1,202,489 | 10 | Teodora Film | false | false |
| 29 | - | Planet 51 | $2,313 | - | 3 | - | $771 | $3,405,781 | 13 | N/A | false | false |
| 30 | 28 | The Hurt Locker | $1,378 | -35.9% | 2 | - | $689 | $176,908 | 71 | Warner Bros. | false | false |
| 31 | - | Brothers | $1,240 | - | 2 | - | $620 | $3,266,025 | 8 | 01 Distribution | false | false |
| 32 | - | The Cézanne Affair/The Man Who Will Come | $1,199 | - | 1 | - | $1,199 | $2,239,181 | 11 | 01 Distribution | false | false |
| 33 | - | Gravehopping | $1,135 | - | 1 | - | $1,135 | $43,057 | 85 | N/A | false | false |
| 34 | 29 | Cado dalle nubi | $1,106 | -34.6% | 2 | - | $553 | $19,573,511 | 12 | Medusa Distribuzione | false | false |
