| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Valentine's Day | $1,042,118 | - | 106 | - | $9,831 | $1,228,438 | 1 | Warner Bros. | true | false |
| 2 | 1 | Avatar | $1,027,554 | -24.3% | 129 | -13 | $7,965 | $20,158,867 | 9 | 20th Century Fox International | false | false |
| 3 | - | Percy Jackson & the Olympians: The Lightning Thief | $450,069 | - | 96 | - | $4,688 | $450,069 | 1 | Warner Bros. | true | false |
| 4 | 2 | The Princess and the Frog | $308,262 | -32.3% | 137 | - | $2,250 | $1,039,764 | 2 | Walt Disney Pictures | false | false |
| 5 | - | The Wolfman | $223,861 | - | 54 | - | $4,145 | $223,861 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 4 | Edge of Darkness | $134,230 | -47.8% | 72 | -6 | $1,864 | $859,641 | 3 | Entertainment One | false | false |
| 7 | 3 | Sherlock Holmes | $119,419 | -59.4% | 75 | -23 | $1,592 | $3,790,113 | 6 | Warner Bros. | false | false |
| 8 | 7 | Alvin and the Chipmunks: The Squeakquel | $103,553 | -40.7% | 107 | -6 | $967 | $6,231,855 | 8 | Warner Bros. | false | false |
| 9 | 5 | Love Life | $89,712 | -57.7% | 90 | -15 | $996 | $12,232,040 | 12 | Benelux Film Distributors | false | false |
| 10 | 13 | A Single Man | $84,651 | -8.5% | 20 | - | $4,232 | $251,760 | 2 | Cinéart | false | false |
| 11 | 10 | The Girl Who Played with Fire | $78,103 | -35.1% | 46 | -10 | $1,697 | $773,081 | 4 | Benelux Film Distributors | false | false |
| 12 | 9 | The Spy Next Door 2010 Re-release | $77,499 | -36.4% | 44 | - | $1,761 | $231,366 | 2 | A-Film Distribution | false | false |
| 13 | 6 | Did You Hear About the Morgans? | $70,537 | -62% | 41 | -6 | $1,720 | $1,088,087 | 4 | Sony Pictures Releasing | false | false |
| 14 | - | My Name Is Khan | $66,925 | - | 5 | - | $13,385 | $66,925 | 1 | Warner Bros. | true | false |
| 15 | 14 | A Prophet | $63,956 | -22.5% | 26 | +2 | $2,459 | $187,258 | 2 | Cinemien | false | false |
| 16 | 11 | The Box | $57,270 | -48.6% | 39 | -5 | $1,468 | $238,452 | 2 | Benelux Film Distributors | false | false |
| 17 | 8 | It's Complicated | $56,012 | -62.7% | 55 | -30 | $1,018 | $3,247,030 | 8 | Universal Pictures International (UPI) | false | false |
| 18 | 12 | Up in the Air | $52,652 | -50.5% | 29 | -7 | $1,815 | $1,074,328 | 5 | Universal Pictures International (UPI) | false | false |
| 19 | 15 | The Imaginarium of Doctor Parnassus | $50,865 | -37.6% | 20 | +2 | $2,543 | $184,903 | 2 | Entertainment One | false | false |
| 20 | 17 | A Serious Man | $50,417 | -30% | 22 | - | $2,291 | $459,888 | 4 | Universal Pictures International (UPI) | false | false |
