| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Valentine's Day | $586,301 | - | 48 | - | $12,214 | $586,301 | 1 | Warner Bros. | true | false |
| 2 | 1 | Avatar | $319,773 | -12.8% | 62 | -13 | $5,157 | $10,481,678 | 9 | 20th Century Fox International | false | false |
| 3 | - | Percy Jackson & the Olympians: The Lightning Thief | $229,280 | - | 59 | - | $3,886 | $229,280 | 1 | 20th Century Fox International | true | false |
| 4 | - | The Wolfman | $135,613 | - | 42 | - | $3,228 | $135,613 | 1 | United International Pictures | true | false |
| 5 | 2 | It's Complicated | $121,331 | -15.4% | 58 | - | $2,091 | $1,195,902 | 4 | United International Pictures | false | false |
| 6 | - | My Name Is Khan | $100,698 | - | 12 | - | $8,391 | $100,698 | 1 | 20th Century Fox International | true | false |
| 7 | 4 | Precious | $77,461 | -7.9% | 30 | - | $2,582 | $206,921 | 2 | Icon Film Distribution | false | false |
| 8 | 3 | Did You Hear About the Morgans? | $56,728 | -46.2% | 57 | - | $995 | $202,956 | 2 | Sony Pictures Releasing | false | false |
| 9 | 5 | Edge of Darkness | $47,298 | -42.2% | 45 | - | $1,051 | $165,584 | 2 | Icon Film Distribution | false | false |
| 10 | 6 | Nine | $41,387 | -39.4% | 30 | - | $1,379 | $355,937 | 55 | Sony Pictures Releasing | false | false |
| 11 | 11 | The Girl with the Dragon Tattoo | $34,228 | +34.3% | 35 | - | $977 | $585,948 | 9 | Rialto Distribution | false | false |
| 12 | 9 | Up in the Air | $33,759 | -21% | 29 | -1 | $1,164 | $526,142 | 5 | Paramount Pictures International | false | false |
| 13 | 7 | Invictus | $32,849 | -37.3% | 44 | -2 | $746 | $287,561 | 3 | Warner Bros. | false | false |
| 14 | 8 | Sherlock Holmes | $24,214 | -46.6% | 46 | -16 | $526 | $2,643,099 | 8 | Roadshow Films | false | false |
| 15 | 14 | Alvin and the Chipmunks: The Squeakquel | $15,736 | -18.3% | 47 | -14 | $334 | $2,683,586 | 8 | 20th Century Fox International | false | false |
| 16 | 10 | The Lovely Bones | $15,736 | -42.3% | 47 | -5 | $334 | $2,683,586 | 8 | Paramount Pictures International | false | false |
| 17 | 13 | Tooth Fairy | $12,637 | -40.2% | 37 | -21 | $341 | $803,308 | 5 | 20th Century Fox International | false | false |
| 18 | 16 | Fantastic Mr. Fox | $10,382 | -19.1% | 21 | -16 | $494 | $539,707 | 6 | 20th Century Fox International | false | false |
| 19 | 18 | The Princess and the Frog | $5,414 | -22.2% | 14 | -16 | $386 | $586,413 | 7 | Walt Disney Pictures | false | false |
| 20 | - | Silent Wedding | $3,705 | - | 3 | - | $1,235 | $3,705 | 1 | Vendetta Films | true | false |
| 21 | 15 | Paranormal Activity | $3,690 | -73.1% | 12 | -19 | $307 | $903,094 | 7 | Icon Film Distribution | false | false |
| 22 | 20 | Charlie & Boots | $3,614 | -25.6% | 15 | -2 | $240 | $11,570 | 2 | Paramount Pictures International | false | false |
| 23 | 22 | Broken Embraces | $3,574 | -7.8% | 5 | -1 | $714 | $20,454 | 3 | Paramount Pictures International | false | false |
| 24 | 17 | Astro Boy | $3,353 | -53.4% | 18 | -23 | $186 | $169,491 | 4 | Hoyts Distribution | false | false |
| 25 | 24 | Julie & Julia | $2,952 | +35.1% | 7 | +1 | $421 | $1,364,343 | 17 | Sony Pictures Releasing | false | false |
| 26 | 21 | The Time Traveler's Wife | $2,555 | -35.5% | 14 | -10 | $182 | $612,976 | 11 | Roadshow Films | false | false |
| 27 | - | Little Big Soldier | $2,531 | - | 4 | - | $632 | $2,531 | 1 | Vendetta Films | true | false |
| 28 | - | Noodle | $1,790 | - | 8 | - | $223 | $18,881 | 4 | - | false | false |
| 29 | 19 | Old Dogs | $1,783 | -70.9% | 11 | -17 | $162 | $520,891 | 6 | Walt Disney Pictures | false | false |
| 30 | 28 | Creation | $1,499 | +67.3% | 16 | +2 | $93 | $113,194 | 8 | Icon Film Distribution | false | false |
| 31 | 30 | My Sister's Keeper | $1,335 | +73.6% | 8 | +2 | $166 | $931,721 | 15 | Roadshow Films | false | false |
| 32 | 25 | The Twilight Saga: New Moon | $1,201 | -29.6% | 6 | -2 | $200 | $4,280,360 | 13 | Hoyts Distribution | false | false |
| 33 | 26 | Where the Wild Things Are | $1,056 | -29.6% | 8 | -10 | $132 | $892,934 | 11 | Roadshow Films | false | false |
| 34 | - | An Education | $954 | - | 4 | - | $238 | $597,167 | 19 | Paramount Pictures International | false | false |
| 35 | 32 | Departures | $883 | +69.2% | 3 | - | $294 | $197,585 | 26 | Madman Entertainment | false | false |
| 36 | - | Valentino: The Last Emperor | $424 | - | 1 | - | $424 | $71,015 | 12 | Hopscotch Films | false | false |
| 37 | 29 | Whip It | $267 | -69.6% | 9 | -1 | $29 | $155,129 | 6 | Roadshow Films | false | false |
| 38 | 34 | Five Minutes of Heaven | $257 | -40.2% | 3 | -1 | $85 | $31,683 | 9 | Madman Entertainment | false | false |
| 39 | - | A Heavenly Vintage | $105 | - | 2 | - | $52 | $134,864 | 14 | Icon Film Distribution | false | false |
| 40 | 35 | Planet 51 | $77 | -62.8% | 3 | -4 | $25 | $285,326 | 10 | Hoyts Distribution | false | false |
| 41 | - | Bandslam | $37 | - | 2 | - | $18 | $83,017 | 9 | Hoyts Distribution | false | false |
