| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Old Dogs | $273,396 | - | 51 | - | $5,360 | $273,396 | 1 | United International Pictures | true | false |
| 2 | 2 | Avatar | $164,447 | -21.9% | 33 | - | $4,983 | $4,693,471 | 8 | 20th Century Fox International | false | false |
| 3 | 1 | Tooth Fairy | $162,510 | -31.9% | 56 | -3 | $2,901 | $1,297,320 | 4 | 20th Century Fox International | false | false |
| 4 | - | Cirque du Freak: The Vampire's Assistant | $116,481 | - | 49 | - | $2,377 | $116,481 | 1 | United International Pictures | true | false |
| 5 | - | Invictus | $78,744 | - | 34 | - | $2,316 | $78,744 | 1 | Warner Bros. | true | false |
| 6 | 3 | Sherlock Holmes | $74,240 | -52.9% | 51 | -23 | $1,455 | $1,089,065 | 4 | Warner Bros. | false | false |
| 7 | 4 | Zombieland | $38,336 | -48.9% | 29 | -1 | $1,321 | $159,553 | 2 | Sony Pictures Releasing | false | false |
| 8 | 5 | Up in the Air | $24,687 | -53.4% | 25 | -10 | $987 | $233,843 | 3 | United International Pictures | false | false |
| 9 | 9 | Nine | $19,823 | -36.9% | 10 | - | $1,982 | $71,480 | 2 | Sony Pictures Releasing | false | false |
| 10 | - | The Time Traveler's Wife | $17,732 | - | 9 | - | $1,970 | $17,732 | 1 | N/A | true | false |
| 11 | 8 | Funny People | $17,607 | -53.1% | 18 | -2 | $978 | $79,044 | 2 | United International Pictures | false | false |
| 12 | 7 | Astro Boy | $15,546 | -58.7% | 15 | - | $1,036 | $64,759 | 2 | N/A | false | false |
| 13 | 6 | Alvin and the Chipmunks: The Squeakquel | $12,098 | -68.3% | 23 | -24 | $526 | $1,732,926 | 7 | 20th Century Fox International | false | false |
| 14 | 13 | Unrest 2009 Re-release | $9,676 | -50.5% | 10 | -2 | $967 | $236,561 | 5 | N/A | false | false |
| 15 | 12 | The Princess and the Frog | $6,936 | -66.5% | 29 | -17 | $239 | $1,988,086 | 9 | Walt Disney Pictures | false | false |
| 16 | 10 | The Stepfather | $6,469 | -77% | 11 | -11 | $588 | $375,834 | 5 | Sony Pictures Releasing | false | false |
| 17 | 11 | Penelope | $5,186 | -78.2% | 6 | -5 | $864 | $43,912 | 2 | N/A | false | false |
| 18 | 15 | All About Steve | $3,997 | -32.9% | 3 | -2 | $1,332 | $495,126 | 11 | 20th Century Fox International | false | false |
| 19 | 14 | The Final Destination | $2,184 | -66.7% | 8 | -4 | $273 | $741,608 | 11 | N/A | false | false |
| 20 | 16 | Ninja Assassin | $833 | -75.7% | 7 | -5 | $119 | $531,874 | 6 | Warner Bros. | false | false |
| 21 | 20 | 2012 | $219 | -74.2% | 4 | -2 | $54 | $8,046,572 | 13 | Sony Pictures Releasing | false | false |
