| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Valentine's Day | $5,862,090 | - | 432 | - | $13,569 | $5,862,090 | 1 | Warner Bros. | true | false |
| 2 | 1 | Avatar | $5,209,447 | -23.4% | 402 | -15 | $12,958 | $121,050,201 | 9 | 20th Century Fox International | false | false |
| 3 | - | The Wolfman | $3,718,940 | - | 404 | - | $9,205 | $3,718,940 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | The Princess and the Frog | $2,363,606 | - | 501 | - | $4,717 | $6,592,422 | 1 | Walt Disney Pictures | true | false |
| 5 | - | Percy Jackson & the Olympians: The Lightning Thief | $2,360,080 | - | 454 | - | $5,198 | $2,360,080 | 1 | 20th Century Fox International | true | false |
| 6 | - | My Name Is Khan | $1,470,793 | - | 91 | - | $16,162 | $1,470,793 | 1 | 20th Century Fox International | true | false |
| 7 | 4 | Invictus | $1,222,155 | -27% | 279 | +4 | $4,380 | $3,867,705 | 2 | Warner Bros. | false | false |
| 8 | - | A Single Man | $788,455 | - | 79 | - | $9,980 | $788,455 | 1 | Icon Film Distribution | true | false |
| 9 | 8 | Alvin and the Chipmunks: The Squeakquel | $666,911 | -41.7% | 428 | -42 | $1,558 | $33,511,935 | 8 | 20th Century Fox International | false | false |
| 10 | 3 | Astro Boy | $663,392 | -61.2% | 424 | +17 | $1,564 | $2,553,773 | 2 | Entertainment One | false | false |
| 11 | 5 | Sherlock Holmes | $615,538 | -49.9% | 292 | -105 | $2,108 | $39,520,814 | 8 | Warner Bros. | false | false |
| 12 | 7 | Youth in Revolt | $578,010 | -50.4% | 280 | - | $2,064 | $2,340,477 | 2 | Momentum Pictures | false | false |
| 13 | 6 | Edge of Darkness | $472,885 | -60.7% | 290 | -122 | $1,630 | $5,187,049 | 3 | Icon Film Distribution | false | false |
| 14 | 9 | It's Complicated | $315,251 | -64.1% | 236 | -176 | $1,335 | $13,881,029 | 6 | Universal Pictures International (UPI) | false | false |
| 15 | 11 | Precious | $285,400 | -50.7% | 82 | -19 | $3,480 | $1,902,694 | 3 | Icon Film Distribution | false | false |
