| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Percy Jackson & the Olympians: The Lightning Thief | $240,668 | - | 54 | - | $4,456 | $240,668 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Old Dogs | $221,496 | -19% | 43 | -8 | $5,151 | $648,768 | 2 | United International Pictures | false | false |
| 3 | - | The Wolfman | $159,968 | - | 48 | - | $3,332 | $159,968 | 1 | United International Pictures | true | false |
| 4 | - | Valentine's Day | $138,309 | - | 44 | - | $3,143 | $138,309 | 1 | Warner Bros. | true | false |
| 5 | 3 | Tooth Fairy | $75,603 | -53.5% | 40 | -16 | $1,890 | $1,436,798 | 5 | 20th Century Fox International | false | false |
| 6 | - | My Bloody Valentine | $73,685 | - | 25 | - | $2,947 | $76,918 | 1 | N/A | true | false |
| 7 | 2 | Avatar | $56,501 | -65.6% | 18 | -15 | $3,138 | $4,841,356 | 9 | 20th Century Fox International | false | false |
| 8 | 4 | Cirque du Freak: The Vampire's Assistant | $54,892 | -52.9% | 33 | -16 | $1,663 | $240,000 | 2 | United International Pictures | false | false |
| 9 | 5 | Invictus | $39,146 | -50.3% | 23 | -11 | $1,702 | $164,427 | 2 | Warner Bros. | false | false |
| 10 | 6 | Sherlock Holmes | $15,819 | -78.7% | 16 | -35 | $988 | $1,145,865 | 5 | Warner Bros. | false | false |
| 11 | 9 | Nine | $12,559 | -36.6% | 4 | -6 | $3,139 | $93,054 | 3 | Sony Pictures Releasing | false | false |
| 12 | 10 | The Time Traveler's Wife | $5,881 | -66.8% | 3 | -6 | $1,960 | $32,698 | 2 | N/A | false | false |
| 13 | 7 | Zombieland | $5,822 | -84.8% | 10 | -19 | $582 | $186,937 | 3 | Sony Pictures Releasing | false | false |
| 14 | 8 | Up in the Air | $4,450 | -82% | 6 | -19 | $741 | $250,811 | 4 | United International Pictures | false | false |
| 15 | 12 | Astro Boy | $3,960 | -74.5% | 10 | -5 | $396 | $72,451 | 3 | N/A | false | false |
| 16 | 13 | Alvin and the Chipmunks: The Squeakquel | $3,776 | -68.8% | 10 | -13 | $377 | $1,740,186 | 8 | 20th Century Fox International | false | false |
| 17 | 11 | Funny People | $1,034 | -94.1% | 2 | -16 | $517 | $92,336 | 3 | United International Pictures | false | false |
| 18 | 15 | The Princess and the Frog | $930 | -86.6% | 1 | -28 | $930 | $1,991,167 | 10 | Walt Disney Pictures | false | false |
| 19 | 18 | All About Steve | $480 | -88% | 1 | -2 | $480 | $561,439 | 12 | 20th Century Fox International | false | false |
| 20 | 14 | Unrest 2009 Re-release | $288 | -97% | 1 | -9 | $288 | $241,113 | 6 | N/A | false | false |
| 21 | 16 | The Stepfather | $221 | -96.6% | 2 | -9 | $110 | $380,295 | 6 | Sony Pictures Releasing | false | false |
| 22 | 17 | Penelope | $37 | -99.3% | 1 | -5 | $37 | $46,290 | 3 | N/A | false | false |
