| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $73,937 | -67.4% | 36 | -20 | $2,053 | $9,707,505 | 11 | 20th Century Fox International | false | false |
| 2 | 3 | Percy Jackson & the Olympians: The Lightning Thief | $44,635 | -63.4% | 32 | -18 | $1,394 | $476,586 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | The Wolfman | $36,572 | -70.3% | 29 | -14 | $1,261 | $506,680 | 3 | United International Pictures | false | false |
| 4 | 4 | Alvin and the Chipmunks: The Squeakquel | $33,642 | -65.8% | 28 | -20 | $1,201 | $1,211,149 | 5 | 20th Century Fox International | false | false |
| 5 | 5 | The Lovely Bones | $22,026 | -67.5% | 23 | -10 | $957 | $126,575 | 2 | United International Pictures | false | false |
| 6 | 6 | Valentine's Day | $10,989 | -78% | 19 | -11 | $578 | $250,206 | 3 | Warner Bros. | false | false |
| 7 | 7 | Sherlock Holmes | $10,820 | -74.6% | 14 | -15 | $772 | $1,212,338 | 6 | Warner Bros. | false | false |
| 8 | 8 | The Hurt Locker | $9,833 | -71.3% | 10 | -11 | $983 | $63,221 | 2 | N/A | false | false |
| 9 | - | Couples Retreat | $8,588 | - | 14 | - | $613 | $8,588 | 1 | United International Pictures | true | false |
| 10 | - | Everybody's Fine | $6,213 | - | 7 | - | $887 | $6,213 | 1 | Walt Disney Pictures | true | false |
| 11 | 10 | Invictus | $5,105 | -76% | 11 | -6 | $464 | $180,826 | 4 | Warner Bros. | false | false |
| 12 | 15 | The Haunting in Connecticut | $4,301 | -37.2% | 7 | -1 | $614 | $136,065 | 7 | Transeuropa | false | false |
| 13 | 11 | Nine | $3,967 | -80.7% | 12 | - | $330 | $32,971 | 2 | Sony Pictures Releasing | false | false |
| 14 | - | Ponyo | $3,120 | - | 4 | - | $780 | $3,120 | 1 | Andes Films | true | false |
| 15 | 14 | Up in the Air | $3,067 | -80.1% | 8 | -2 | $383 | $129,779 | 4 | United International Pictures | false | false |
| 16 | 13 | It's Complicated | $2,586 | -83.6% | 4 | -4 | $646 | $225,637 | 5 | United International Pictures | false | false |
| 17 | - | Precious | $2,564 | - | 2 | - | $1,282 | $2,564 | 1 | N/A | true | false |
| 18 | 9 | Toy Story 2 2009 Re-release | $2,439 | -88.6% | 8 | -5 | $304 | $33,235 | 2 | Walt Disney Pictures | false | false |
| 19 | 12 | Toy Story 2009 Re-release | $2,254 | -85.8% | 7 | -6 | $322 | $24,755 | 2 | Walt Disney Pictures | false | false |
| 20 | 18 | The Imaginarium of Doctor Parnassus | $1,328 | -64.1% | 3 | +1 | $442 | $78,155 | 5 | Sony Pictures Releasing | false | false |
| 21 | 20 | Igor | $1,223 | -23.9% | 6 | -5 | $203 | $20,311 | 3 | N/A | false | false |
| 22 | 16 | Astro Boy | $551 | -89.1% | 1 | -7 | $551 | $181,885 | 6 | N/A | false | false |
| 23 | 22 | Planet 51 | $477 | -54.7% | 10 | -3 | $47 | $269,421 | 14 | N/A | false | false |
| 24 | 19 | Ninja Assassin | $313 | -86% | 4 | -1 | $78 | $91,744 | 5 | Warner Bros. | false | false |
| 25 | 24 | Old Dogs | $256 | -49.4% | 1 | - | $256 | $357,715 | 10 | Walt Disney Pictures | false | false |
| 26 | 23 | Saw VI | $174 | -77.2% | 1 | -1 | $174 | $168,638 | 6 | Walt Disney Pictures | false | false |
| 27 | 25 | The Princess and the Frog | $110 | -56.7% | 1 | - | $110 | $904,105 | 13 | Walt Disney Pictures | false | false |
| 28 | 21 | Tooth Fairy | $94 | -92.5% | 1 | -2 | $94 | $519,378 | 8 | 20th Century Fox International | false | false |
