| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Valentine's Day | $41,013 | -40.4% | 9 | - | $4,557 | $185,451 | 2 | Warner Bros. | false | false |
| 2 | 2 | Alvin and the Chipmunks: The Squeakquel | $35,449 | -38.3% | 13 | - | $2,726 | $528,218 | 5 | 20th Century Fox International | false | false |
| 3 | 3 | Avatar | $31,806 | -32.8% | 18 | - | $1,767 | $1,800,924 | 11 | 20th Century Fox International | false | false |
| 4 | 4 | The Wolfman | $22,462 | -38.4% | 7 | - | $3,208 | $85,883 | 2 | United International Pictures | false | false |
| 5 | - | Legion | $13,995 | - | 5 | - | $2,799 | $13,995 | 1 | Sony Pictures Releasing | true | false |
| 6 | 6 | Cloudy with a Chance of Meatballs | $12,216 | -19.2% | 13 | - | $939 | $48,942 | 3 | Sony Pictures Releasing | false | false |
| 7 | - | Invictus | $10,443 | - | 5 | - | $2,088 | $16,195 | 1 | Warner Bros. | true | false |
| 8 | 5 | Did You Hear About the Morgans? | $9,058 | -45.7% | 8 | - | $1,132 | $112,181 | 4 | Sony Pictures Releasing | false | false |
| 9 | 7 | The Princess and the Frog | $8,882 | -25.9% | 9 | - | $986 | $111,781 | 6 | Walt Disney Pictures | false | false |
| 10 | - | The Lovely Bones | $5,634 | - | 5 | - | $1,126 | $7,819 | 1 | United International Pictures | true | false |
| 11 | 8 | Edge of Darkness | $4,381 | -14% | 4 | - | $1,095 | $24,520 | 3 | N/A | false | false |
| 12 | 9 | The Men Who Stare at Goats | $3,453 | -32.1% | 4 | - | $863 | $69,907 | 5 | N/A | false | false |
| 13 | 11 | Up in the Air | $2,845 | -22.9% | 5 | - | $569 | $125,379 | 7 | United International Pictures | false | false |
| 14 | 13 | The Hurt Locker | $2,244 | -26.6% | 2 | - | $1,122 | $12,265 | 2 | N/A | false | false |
| 15 | 10 | Sherlock Holmes | $2,136 | -52.5% | 9 | - | $237 | $261,903 | 8 | Warner Bros. | false | false |
| 16 | 14 | An Education | $1,610 | -26.4% | 2 | - | $805 | $6,646 | 2 | N/A | false | false |
| 17 | 12 | The Book of Eli | $1,408 | -58.1% | 6 | - | $234 | $90,552 | 6 | N/A | false | false |
