| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $9,424,165 | - | 448 | - | $21,036 | $9,424,165 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | The Blind Side | $1,568,701 | -31.8% | 222 | +1 | $7,066 | $5,053,131 | 2 | Roadshow Films | false | false |
| 3 | - | Dear John | $1,517,467 | - | 196 | - | $7,742 | $1,517,467 | 1 | Roadshow Films | true | false |
| 4 | 2 | Shutter Island | $1,096,123 | -39.8% | 245 | -5 | $4,473 | $7,074,646 | 3 | Paramount Pictures International | false | false |
| 5 | 3 | Avatar | $911,345 | -40.5% | 205 | -24 | $4,445 | $99,479,736 | 12 | 20th Century Fox International | false | false |
| 6 | 4 | Valentine's Day | $515,840 | -62% | 323 | -43 | $1,597 | $13,868,332 | 4 | Warner Bros. | false | false |
| 7 | 6 | The Hurt Locker | $462,795 | -9% | 48 | +2 | $9,641 | $1,674,001 | 3 | Roadshow Films | false | false |
| 8 | - | The Men Who Stare at Goats | $435,304 | - | 58 | - | $7,505 | $479,414 | 1 | Sony Pictures Releasing | true | false |
| 9 | 5 | Percy Jackson & the Olympians: The Lightning Thief | $337,048 | -52.8% | 195 | -23 | $1,728 | $4,233,503 | 4 | 20th Century Fox International | false | false |
| 10 | 7 | From Paris with Love | $230,233 | -48.6% | 137 | -20 | $1,680 | $1,569,793 | 3 | Hoyts Distribution | false | false |
| 11 | 9 | A Single Man | $199,194 | -15.3% | 26 | - | $7,661 | $578,586 | 2 | Icon Film Distribution | false | false |
| 12 | 8 | The Wolfman | $149,516 | -62.4% | 156 | -62 | $958 | $3,774,847 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 12 | Crazy Heart | $111,180 | -14.7% | 76 | +18 | $1,462 | $586,236 | 3 | 20th Century Fox International | false | false |
| 14 | 10 | Up in the Air | $102,756 | -40.8% | 84 | -26 | $1,223 | $7,227,182 | 8 | Paramount Pictures International | false | false |
| 15 | 11 | Bran Nue Dae | $70,073 | -51% | 93 | -24 | $753 | $6,567,383 | 8 | Roadshow Films | false | false |
| 16 | 16 | Precious | $69,858 | -19.3% | 40 | +7 | $1,746 | $965,405 | 5 | Icon Film Distribution | false | false |
| 17 | 13 | Invictus | $64,923 | -48.2% | 75 | -24 | $865 | $6,311,051 | 7 | Warner Bros. | false | false |
| 18 | 14 | It's Complicated | $61,378 | -46.7% | 103 | - | $595 | $14,187,266 | 9 | Universal Pictures International (UPI) | false | false |
| 19 | - | Law Abiding Citizen | $43,300 | - | 31 | - | $1,396 | $4,479,603 | 6 | Roadshow Films | false | false |
| 20 | 15 | Tooth Fairy | $32,566 | -64.4% | 45 | -50 | $723 | $9,475,680 | 8 | 20th Century Fox International | false | false |
| 21 | - | Atithi Tum Kab Jaoge? | $20,171 | - | 5 | - | $4,034 | $20,171 | 1 | Saini Enterprises | true | false |
| 22 | - | Separation City | $13,875 | - | 15 | - | $925 | $13,875 | 1 | Hoyts Distribution | true | false |
| 23 | - | My One and Only | $7,392 | - | 19 | - | $389 | $7,392 | - | Hopscotch Films | - | false |
