| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $11,115,961 | - | 668 | - | $16,640 | $14,327,515 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Genitori & figli:) - Agitare bene prima dell'uso | $2,723,478 | -28.4% | 462 | -9 | $5,894 | $7,928,253 | 2 | Filmauro | false | false |
| 3 | - | Shutter Island | $2,637,858 | - | 433 | - | $6,092 | $2,637,858 | 1 | Medusa Distribuzione | true | false |
| 4 | 2 | Invictus | $1,903,162 | -28.1% | 413 | -5 | $4,608 | $5,688,994 | 2 | Warner Bros. | false | false |
| 5 | 3 | Avatar | $1,082,038 | -58.2% | 184 | -126 | $5,880 | $86,523,977 | 8 | 20th Century Fox International | false | false |
| 6 | 4 | The Book of Eli | $848,968 | -52.8% | 288 | -43 | $2,947 | $3,332,700 | 2 | 01 Distribution | false | false |
| 7 | 5 | The Wolfman | $468,023 | -61.1% | 193 | -160 | $2,424 | $5,688,856 | 3 | United International Pictures | false | false |
| 8 | 9 | The Concert | $301,133 | -13.1% | 79 | -3 | $3,811 | $3,441,816 | 5 | BIM Distribuzione | false | false |
| 9 | 8 | Did You Hear About the Morgans? | $215,067 | -62.5% | 116 | -109 | $1,854 | $2,441,641 | 3 | Sony Pictures Releasing | false | false |
| 10 | 6 | The Youngest Son | $198,911 | -68.1% | 113 | -192 | $1,760 | $2,743,436 | 3 | Medusa Distribuzione | false | false |
| 11 | 10 | Alvin and the Chipmunks: The Squeakquel | $148,191 | -53.4% | 106 | -53 | $1,398 | $8,159,552 | 6 | 20th Century Fox International | false | false |
| 12 | - | Partir | $147,191 | - | 43 | - | $3,423 | $147,191 | 1 | Teodora Film | true | false |
| 13 | 7 | Sorry If I Want to Marry You | $133,103 | -78.5% | 84 | -176 | $1,584 | $9,217,708 | 4 | Medusa Distribuzione | false | false |
| 14 | 12 | Lilly the Witch: The Dragon and the Magic Book | $73,680 | -62% | 77 | -46 | $956 | $1,205,136 | 4 | Walt Disney Pictures | false | false |
| 15 | 13 | The First Beautiful Thing | $69,224 | -44.6% | 27 | -13 | $2,563 | $8,669,896 | 8 | Medusa Distribuzione | false | false |
| 16 | 15 | Up in the Air | $41,865 | -54.5% | 19 | -20 | $2,203 | $7,645,175 | 7 | United International Pictures | false | false |
| 17 | 17 | The Man Who Will Come | $40,780 | -12.9% | 19 | -5 | $2,146 | $1,456,008 | 7 | Mikado Film | false | false |
| 18 | 11 | Le missionnaire | $36,323 | -84.5% | 26 | -104 | $1,397 | $1,072,505 | 3 | Eagle Pictures | false | false |
| 19 | - | Revanche | $34,558 | - | 20 | - | $1,727 | $34,558 | 1 | Fandango | true | false |
| 20 | 20 | The Mouth of the Wolf | $29,841 | -22.3% | 16 | -1 | $1,865 | $154,636 | 3 | BIM Distribuzione | false | false |
| 21 | - | Crazy Heart | $25,759 | - | 10 | - | $2,575 | $25,759 | 1 | 20th Century Fox International | true | false |
| 22 | 16 | Kiss Me Again | $25,253 | -61.3% | 14 | -19 | $1,803 | $12,360,071 | 6 | Medusa Distribuzione | false | false |
| 23 | - | North | $23,913 | - | 12 | - | $1,992 | $86,640 | 2 | Sacher Distribuzione | false | false |
| 24 | 21 | A Single Man | $22,455 | -32.6% | 12 | - | $1,871 | $1,496,799 | 8 | N/A | false | false |
| 25 | 25 | Soul Kitchen | $21,624 | -27.1% | 7 | -4 | $3,089 | $2,281,939 | 9 | BIM Distribuzione | false | false |
| 26 | 19 | Lourdes | $17,101 | -55.8% | 13 | -16 | $1,315 | $455,962 | 4 | N/A | false | false |
| 27 | 22 | An Education | $12,326 | -60.9% | 12 | -4 | $1,027 | $481,360 | 5 | Sony Pictures Releasing | false | false |
| 28 | - | Diamond 13 | $9,694 | - | 6 | - | $1,615 | $9,694 | 1 | N/A | true | false |
| 29 | 28 | Incendiary | $9,291 | -11.3% | 6 | -3 | $1,548 | $34,512 | 2 | N/A | false | false |
| 30 | 14 | The Lovely Bones | $7,244 | -92.6% | 8 | -42 | $905 | $2,396,608 | 4 | United International Pictures | false | false |
| 31 | 32 | Cloudy with a Chance of Meatballs | $6,429 | +26.9% | 46 | +16 | $139 | $8,260,451 | 11 | Sony Pictures Releasing | false | false |
| 32 | 30 | Me, Them and Lara | $5,398 | -39.9% | 6 | -2 | $899 | $21,347,896 | 9 | Warner Bros. | false | false |
| 33 | 24 | Call of the Wild | $4,666 | -84.3% | 9 | -19 | $518 | $122,334 | 3 | N/A | false | false |
