| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $38,692 | - | 6 | - | $6,448 | $46,398 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Avatar | $26,526 | -34.6% | 14 | - | $1,894 | $1,234,092 | 12 | 20th Century Fox International | false | false |
| 3 | 2 | The Wolfman | $12,369 | -33.7% | 6 | - | $2,061 | $48,479 | 2 | United International Pictures | false | false |
| 4 | 3 | Percy Jackson & the Olympians: The Lightning Thief | $8,933 | -19% | 7 | - | $1,276 | $24,805 | 2 | 20th Century Fox International | false | false |
| 5 | 4 | Valentine's Day | $7,451 | -24.4% | 6 | - | $1,241 | $113,973 | 4 | Warner Bros. | false | false |
| 6 | - | Invictus 2010 Re-release | $4,472 | - | 4 | - | $1,118 | $18,404 | 1 | Warner Bros. | true | false |
| 7 | 7 | The Lovely Bones | $2,616 | -33.6% | 5 | - | $523 | $23,924 | 3 | United International Pictures | false | false |
| 8 | 6 | The Princess and the Frog | $2,420 | -54.3% | 6 | - | $403 | $59,442 | 6 | Walt Disney Pictures | false | false |
| 9 | 9 | The Imaginarium of Doctor Parnassus | $2,330 | -30% | 2 | - | $1,165 | $29,063 | 4 | N/A | false | false |
| 10 | 5 | Toy Story 2009 Re-release | $2,269 | -64.8% | 3 | - | $756 | $25,837 | 4 | Walt Disney Pictures | false | false |
| 11 | 8 | Sherlock Holmes | $2,156 | -44.7% | 6 | - | $359 | $218,329 | 9 | Warner Bros. | false | false |
| 12 | 11 | Alvin and the Chipmunks: The Squeakquel | $1,581 | -43.9% | 6 | - | $263 | $54,496 | 8 | 20th Century Fox International | false | false |
| 13 | 10 | Law Abiding Citizen | $1,352 | -53.9% | 5 | - | $270 | $19,284 | 3 | N/A | false | false |
| 14 | - | Pope Joan | $1,290 | - | 2 | - | $645 | $7,137 | 1 | N/A | true | false |
| 15 | 15 | Nine | $1,236 | -18.2% | 4 | - | $309 | $28,618 | 5 | N/A | false | false |
| 16 | 12 | Arthur and the Revenge of Maltazard | $1,127 | -55.7% | 6 | - | $187 | $60,094 | 10 | N/A | false | false |
| 17 | - | Antichrist | $743 | - | 1 | - | $743 | $11,091 | 1 | N/A | true | false |
| 18 | 13 | Did You Hear About the Morgans? | $732 | -58.9% | 6 | +1 | $122 | $84,851 | 7 | Sony Pictures Releasing | false | false |
| 19 | 16 | Don't Look Back | $525 | -50% | 2 | - | $262 | $12,371 | 2 | N/A | false | false |
| 20 | 19 | The White Ribbon | $391 | +21.8% | 1 | - | $391 | $12,234 | 3 | N/A | false | false |
| 21 | 23 | The Flight Before Christmas | $367 | +216.4% | 3 | - | $122 | $12,811 | 13 | N/A | false | false |
| 22 | 18 | Garfield's Fun Fest | $290 | -68.2% | 2 | - | $145 | $13,372 | 11 | N/A | false | false |
| 23 | 14 | Up in the Air | $251 | -84.9% | 5 | - | $50 | $44,356 | 5 | United International Pictures | false | false |
| 24 | 21 | It's Complicated | $196 | +42% | 9 | - | $21 | $114,199 | 11 | United International Pictures | false | false |
| 25 | 17 | Old Dogs | $134 | -86.5% | 5 | - | $26 | $73,182 | 8 | Walt Disney Pictures | false | false |
| 26 | - | The Countess | $92 | - | 1 | - | $92 | $5,198 | 8 | N/A | false | false |
| 27 | 22 | Paranormal Activity | $41 | -65.8% | 5 | - | $8 | $56,508 | 15 | N/A | false | false |
| 28 | 26 | The Box | $39 | -54.1% | 2 | - | $19 | $9,840 | 8 | N/A | false | false |
| 29 | 20 | The Twilight Saga: New Moon | $35 | -86.2% | 5 | - | $7 | $107,146 | 14 | N/A | false | false |
