| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $5,919,561 | -37.2% | 448 | - | $13,213 | $18,802,663 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Green Zone | $1,810,642 | - | 245 | - | $7,390 | $1,810,642 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | The Blind Side | $1,305,568 | -16.8% | 206 | -16 | $6,337 | $7,230,886 | 3 | Roadshow Films | false | false |
| 4 | 3 | Dear John | $821,731 | -45.8% | 189 | -7 | $4,347 | $2,918,290 | 2 | Roadshow Films | false | false |
| 5 | 7 | The Hurt Locker | $740,108 | +59.9% | 71 | +23 | $10,424 | $2,760,488 | 4 | Roadshow Films | false | false |
| 6 | 5 | Avatar | $715,232 | -21.5% | 165 | -40 | $4,334 | $101,530,751 | 13 | 20th Century Fox International | false | false |
| 7 | 4 | Shutter Island | $612,482 | -44.1% | 228 | -17 | $2,686 | $8,180,962 | 4 | Paramount Pictures International | false | false |
| 8 | - | Remember Me | $467,773 | - | 173 | - | $2,703 | $475,349 | 1 | Hoyts Distribution | true | false |
| 9 | 8 | The Men Who Stare at Goats | $246,294 | -43.4% | 58 | - | $4,246 | $903,893 | 2 | Sony Pictures Releasing | false | false |
| 10 | 6 | Valentine's Day | $191,166 | -62.9% | 186 | -137 | $1,027 | $14,392,183 | 5 | Warner Bros. | false | false |
| 11 | 11 | A Single Man | $139,849 | -29.8% | 27 | +1 | $5,179 | $822,082 | 3 | Icon Film Distribution | false | false |
| 12 | 9 | Percy Jackson & the Olympians: The Lightning Thief | $125,924 | -62.6% | 143 | -52 | $880 | $4,504,188 | 5 | 20th Century Fox International | false | false |
| 13 | 13 | Crazy Heart | $102,320 | -8% | 72 | -4 | $1,421 | $774,030 | 4 | 20th Century Fox International | false | false |
| 14 | 10 | From Paris with Love | $68,456 | -70.3% | 74 | -63 | $925 | $1,743,558 | 4 | Hoyts Distribution | false | false |
| 15 | 16 | Precious | $66,721 | -4.5% | 50 | +10 | $1,334 | $1,089,037 | 6 | Icon Film Distribution | false | false |
| 16 | 14 | Up in the Air | $59,749 | -41.9% | 64 | -20 | $933 | $7,424,628 | 9 | Paramount Pictures International | false | false |
| 17 | - | The Lovely Bones | $45,230 | - | 9 | - | $5,025 | $6,089,234 | 12 | Paramount Pictures International | false | false |
| 18 | - | My One and Only | $43,572 | - | 20 | - | $2,178 | $53,093 | 1 | Hopscotch Films | true | false |
| 19 | 15 | Bran Nue Dae | $41,678 | -40.5% | 73 | -20 | $570 | $6,698,962 | 9 | Roadshow Films | false | false |
| 20 | 17 | Invictus | $36,176 | -44.3% | 61 | -14 | $593 | $6,432,362 | 8 | Warner Bros. | false | false |
| 21 | - | Cirque du Freak: The Vampire's Assistant | $36,040 | - | 41 | - | $879 | $36,040 | 1 | Universal Pictures International (UPI) | true | false |
