| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $8,311,436 | -25.2% | 646 | -22 | $12,866 | $27,813,712 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Loose Cannons | $2,861,655 | - | 427 | - | $6,701 | $2,863,304 | 1 | 01 Distribution | true | false |
| 3 | 3 | Shutter Island | $1,810,786 | -31.4% | 374 | -59 | $4,841 | $5,520,796 | 2 | Medusa Distribuzione | false | false |
| 4 | - | Percy Jackson & the Olympians: The Lightning Thief | $1,625,198 | - | 288 | - | $5,643 | $1,625,198 | 1 | 20th Century Fox International | true | false |
| 5 | 2 | Genitori & figli:) - Agitare bene prima dell'uso | $1,308,020 | -52% | 319 | -143 | $4,100 | $10,075,790 | 3 | Filmauro | false | false |
| 6 | - | Valentine's Day | $1,015,625 | - | 295 | - | $3,442 | $1,015,625 | 1 | Warner Bros. | true | false |
| 7 | 4 | Invictus | $856,355 | -55% | 246 | -167 | $3,481 | $7,202,675 | 3 | Warner Bros. | false | false |
| 8 | 5 | Avatar | $683,863 | -36.8% | 109 | -75 | $6,273 | $88,595,544 | 9 | 20th Century Fox International | false | false |
| 9 | - | Legion | $409,518 | - | 125 | - | $3,276 | $409,518 | 1 | Sony Pictures Releasing | true | false |
| 10 | 6 | The Book of Eli | $253,510 | -70.1% | 98 | -190 | $2,586 | $3,867,367 | 3 | 01 Distribution | false | false |
| 11 | - | La valigia sul letto | $230,659 | - | 85 | - | $2,713 | $230,659 | 1 | Medusa Distribuzione | true | false |
| 12 | - | Chloe | $205,460 | - | 87 | - | $2,361 | $205,460 | 1 | Eagle Pictures | true | false |
| 13 | 8 | The Concert | $200,558 | -33.4% | 52 | -27 | $3,856 | $3,790,857 | 6 | BIM Distribuzione | false | false |
| 14 | - | Women Without Men | $104,694 | - | 33 | - | $3,172 | $104,694 | 1 | BIM Distribuzione | true | false |
| 15 | 12 | Partir | $76,941 | -47.7% | 35 | -8 | $2,198 | $104,694 | 2 | Teodora Film | false | false |
| 16 | 7 | The Wolfman | $57,694 | -87.7% | 30 | -163 | $1,923 | $5,937,460 | 4 | United International Pictures | false | false |
| 17 | 11 | Alvin and the Chipmunks: The Squeakquel | $32,934 | -77.8% | 51 | -55 | $645 | $8,297,641 | 7 | 20th Century Fox International | false | false |
| 18 | 10 | The Youngest Son | $31,144 | -84.3% | 21 | -92 | $1,483 | $2,862,647 | 4 | Medusa Distribuzione | false | false |
| 19 | - | The Hurt Locker | $28,651 | - | 14 | - | $2,046 | $218,918 | 75 | Warner Bros. | false | false |
| 20 | 15 | The First Beautiful Thing | $21,816 | -68.5% | 9 | -18 | $2,424 | $8,807,004 | 9 | Medusa Distribuzione | false | false |
| 21 | 21 | Crazy Heart | $21,004 | -18.5% | 10 | - | $2,100 | $60,339 | 2 | 20th Century Fox International | false | false |
| 22 | 17 | The Man Who Will Come | $19,856 | -51.3% | 8 | -11 | $2,482 | $1,498,097 | 8 | Mikado Film | false | false |
| 23 | 14 | Lilly the Witch: The Dragon and the Magic Book | $15,726 | -78.7% | 32 | -45 | $491 | $1,225,130 | 5 | Walt Disney Pictures | false | false |
| 24 | 16 | Up in the Air | $13,812 | -67% | 6 | -13 | $2,302 | $7,634,342 | 8 | United International Pictures | false | false |
| 25 | 25 | Soul Kitchen | $11,854 | -45.2% | 5 | -2 | $2,370 | $2,307,909 | 10 | BIM Distribuzione | false | false |
| 26 | 20 | The Mouth of the Wolf | $10,925 | -63.4% | 8 | -8 | $1,365 | $179,376 | 4 | BIM Distribuzione | false | false |
| 27 | 27 | An Education | $10,676 | -13.4% | 14 | +2 | $762 | $505,859 | 6 | Sony Pictures Releasing | false | false |
| 28 | 29 | Incendiary | $9,956 | +7.2% | 7 | +1 | $1,422 | $59,717 | 3 | N/A | false | false |
| 29 | 28 | Diamond 13 | $9,356 | -3.5% | 6 | - | $1,559 | $36,301 | 2 | N/A | false | false |
| 30 | 23 | North | $8,186 | -65.8% | 5 | -7 | $1,637 | $105,216 | 3 | Sacher Distribuzione | false | false |
| 31 | 22 | Kiss Me Again | $7,587 | -70% | 6 | -8 | $1,264 | $12,373,612 | 7 | Medusa Distribuzione | false | false |
| 32 | 19 | Revanche | $7,584 | -78.1% | 8 | -12 | $948 | $54,030 | 2 | Fandango | false | false |
| 33 | 26 | Lourdes | $7,124 | -58.3% | 6 | -7 | $1,187 | $473,738 | 5 | N/A | false | false |
| 34 | 9 | Did You Hear About the Morgans? | $6,048 | -97.2% | 20 | -96 | $302 | $2,598,671 | 4 | Sony Pictures Releasing | false | false |
| 35 | 13 | Sorry If I Want to Marry You | $5,200 | -96.1% | 3 | -81 | $1,733 | $9,217,837 | 5 | Medusa Distribuzione | false | false |
| 36 | 31 | Cloudy with a Chance of Meatballs | $1,704 | -73.5% | 11 | -35 | $154 | $8,518,335 | 12 | Sony Pictures Releasing | false | false |
