| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $1,747,120 | - | 169 | - | $10,337 | $2,462,737 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Avatar | $388,390 | -31.1% | 72 | -28 | $5,394 | $24,545,948 | 13 | 20th Century Fox International | false | false |
| 3 | - | Dear John | $378,240 | - | 81 | - | $4,669 | $468,319 | 1 | A-Film Distribution | true | false |
| 4 | 2 | Shutter Island | $242,150 | -18.3% | 52 | +1 | $4,656 | $1,876,593 | 4 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | The Book of Eli | $194,185 | -27.5% | 54 | +2 | $3,596 | $600,161 | 2 | Paradiso Entertainment | false | false |
| 6 | 5 | Cloudy with a Chance of Meatballs | $132,933 | -20.7% | 82 | -3 | $1,621 | $2,254,362 | 4 | Sony Pictures Releasing | false | false |
| 7 | 9 | Eep! 2010 Re-release | $110,505 | -10.4% | 90 | +2 | $1,227 | $1,473,739 | 4 | Independent Films | false | false |
| 8 | 7 | Gangsterboys | $106,194 | -32.9% | 39 | - | $2,722 | $1,277,070 | 4 | Independent Films | false | false |
| 9 | 4 | Valentine's Day | $97,945 | -51.3% | 95 | -11 | $1,031 | $3,314,245 | 5 | Warner Bros. | false | false |
| 10 | - | Bad Lieutenant: Port of Call New Orleans | $97,238 | - | 37 | - | $2,628 | $125,754 | 1 | Benelux Film Distributors | true | false |
| 11 | 6 | The Lovely Bones | $94,988 | -41% | 54 | - | $1,759 | $699,658 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | The Princess and the Frog | $83,018 | -20.9% | 109 | -8 | $761 | $2,899,920 | 6 | Walt Disney Pictures | false | false |
| 13 | 10 | Invictus | $80,294 | -25% | 27 | - | $2,973 | $238,480 | 2 | Warner Bros. | false | false |
| 14 | 12 | Chloe | $72,936 | -28.9% | 39 | - | $1,870 | $213,073 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 8 | Percy Jackson & the Olympians: The Lightning Thief | $67,611 | -48.2% | 77 | -18 | $878 | $1,916,462 | 5 | Warner Bros. | false | false |
| 16 | 13 | A Single Man | $55,274 | -6.3% | 20 | - | $2,763 | $679,972 | 6 | Cinéart | false | false |
| 17 | 14 | Alvin and the Chipmunks: The Squeakquel | $49,521 | -4.3% | 93 | -4 | $532 | $7,156,650 | 12 | Warner Bros. | false | false |
| 18 | 17 | The Girl Who Played with Fire | $35,732 | +6.5% | 32 | +4 | $1,116 | $1,072,278 | 8 | Benelux Film Distributors | false | false |
| 19 | - | The Hurt Locker | $32,326 | - | 12 | - | $2,693 | $85,813 | 5 | Independent Films | false | false |
| 20 | 16 | A Prophet | $32,119 | -22% | 25 | -1 | $1,284 | $463,100 | 6 | Cinemien | false | false |
| 21 | - | Two Eyes Staring | $26,804 | - | 26 | - | $1,030 | $26,804 | 1 | N/A | true | false |
| 22 | - | Lourdes | $8,719 | - | 11 | - | $792 | $8,719 | 1 | N/A | true | false |
| 23 | - | Bloody Fox | $1,713 | - | 3 | - | $571 | $1,713 | 1 | N/A | true | false |
| 24 | - | Videocracy | $1,256 | - | 3 | - | $418 | $1,256 | 1 | N/A | true | false |
| 25 | - | Great Kills Road | $481 | - | 3 | - | $160 | $481 | 1 | N/A | true | false |
