| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $103,320 | +24.2% | 27 | -5 | $3,826 | $19,228,646 | 14 | 20th Century Fox International | false | false |
| 2 | 3 | Percy Jackson & the Olympians: The Lightning Thief | $53,260 | +18.3% | 35 | +7 | $1,521 | $1,356,158 | 6 | 20th Century Fox International | false | false |
| 3 | 2 | The Hurt Locker | $46,756 | -13.4% | 17 | -1 | $2,750 | $234,933 | 5 | N/A | false | false |
| 4 | 4 | The Wolfman | $39,723 | +9% | 31 | +6 | $1,281 | $712,567 | 6 | United International Pictures | false | false |
| 5 | 5 | Alvin and the Chipmunks: The Squeakquel | $34,768 | +4.6% | 35 | +10 | $993 | $1,360,567 | 8 | 20th Century Fox International | false | false |
| 6 | - | [Rec]² | $30,870 | - | 14 | - | $2,205 | $30,870 | 1 | N/A | true | false |
| 7 | - | The Blind Side | $24,527 | - | 8 | - | $3,065 | $24,527 | 1 | Warner Bros. | true | false |
| 8 | - | My Best Friend's Girl | $22,445 | - | 15 | - | $1,496 | $22,445 | 1 | Transeuropa | true | false |
| 9 | 6 | 500 Days of Summer | $21,466 | -7.6% | 7 | - | $3,066 | $102,164 | 2 | 20th Century Fox International | false | false |
| 10 | 8 | The Lovely Bones | $19,933 | +9.9% | 20 | +2 | $996 | $233,115 | 5 | United International Pictures | false | false |
| 11 | 7 | Halloween II | $13,066 | -42.5% | 15 | -1 | $871 | $45,770 | 2 | N/A | false | false |
| 12 | 12 | The Haunting in Connecticut | $8,653 | +20.8% | 5 | -1 | $1,730 | $169,633 | 10 | Transeuropa | false | false |
| 13 | 9 | Valentine's Day | $8,141 | -18.8% | 11 | -3 | $740 | $307,281 | 6 | Warner Bros. | false | false |
| 14 | 10 | Precious | $7,081 | -26.4% | 4 | - | $1,770 | $37,734 | 4 | N/A | false | false |
| 15 | 21 | Toy Story 2 2009 Re-release | $6,005 | +161.7% | 5 | - | $1,201 | $44,163 | 5 | Walt Disney Pictures | false | false |
| 16 | 15 | Sherlock Holmes | $5,621 | -14.6% | 9 | - | $624 | $1,260,562 | 9 | Warner Bros. | false | false |
| 17 | 14 | Ponyo | $5,081 | -26.8% | 5 | -3 | $1,016 | $30,816 | 4 | Andes Films | false | false |
| 18 | 20 | Toy Story 2009 Re-release | $4,925 | +73.7% | 5 | - | $985 | $36,299 | 5 | Walt Disney Pictures | false | false |
| 19 | 13 | Welcome to the Sticks | $4,389 | -38.3% | 4 | -2 | $1,097 | $25,378 | 2 | N/A | false | false |
| 20 | 25 | The Imaginarium of Doctor Parnassus | $3,409 | +481.7% | 4 | +2 | $852 | $83,315 | 8 | Sony Pictures Releasing | false | false |
| 21 | 19 | Up in the Air | $3,376 | +4.1% | 4 | +1 | $844 | $142,085 | 7 | United International Pictures | false | false |
| 22 | 22 | Invictus | $2,912 | +108.9% | 5 | +3 | $582 | $196,068 | 7 | Warner Bros. | false | false |
| 23 | 18 | Nine | $2,755 | -23% | 7 | +1 | $393 | $46,949 | 5 | Sony Pictures Releasing | false | false |
| 24 | - | My Stars | $2,353 | - | 4 | - | $588 | $4,459 | 1 | N/A | true | false |
| 25 | 17 | Everybody's Fine | $2,315 | -36.8% | 6 | -2 | $385 | $28,099 | 4 | Walt Disney Pictures | false | false |
| 26 | 16 | It's Complicated | $2,241 | -55.4% | 4 | - | $560 | $243,953 | 8 | United International Pictures | false | false |
| 27 | 23 | Astro Boy | $2,223 | +132.5% | 10 | - | $222 | $356,152 | 9 | N/A | false | false |
| 28 | 11 | Couples Retreat | $1,656 | -78.9% | 7 | -6 | $236 | $46,248 | 4 | United International Pictures | false | false |
| 29 | 24 | Tooth Fairy | $1,222 | +83.2% | 1 | - | $1,222 | $525,982 | 11 | 20th Century Fox International | false | false |
| 30 | - | An Education | $393 | - | 5 | - | $78 | $26,142 | 9 | Sony Pictures Releasing | false | false |
