| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $905,799 | -16.9% | 157 | -4 | $5,769 | $3,910,152 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Book of Eli | $196,021 | - | 75 | - | $2,613 | $196,021 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Edge of Darkness | $84,187 | -43.4% | 49 | -9 | $1,718 | $278,250 | 2 | Warner Bros. | false | false |
| 4 | 3 | Shutter Island | $69,391 | -25.5% | 33 | +8 | $2,102 | $192,741 | 2 | United International Pictures | false | false |
| 5 | 4 | Avatar | $50,601 | -25% | 10 | -2 | $5,060 | $13,473,771 | 14 | 20th Century Fox International | false | false |
| 6 | 5 | [Rec]² | $26,285 | -51.7% | 20 | -9 | $1,314 | $189,534 | 3 | Cine Colombia | false | false |
| 7 | 8 | Couples Retreat | $18,857 | -46.1% | 23 | -4 | $819 | $192,439 | 4 | United International Pictures | false | false |
| 8 | 13 | Invictus | $17,400 | -1.5% | 25 | +6 | $696 | $386,061 | 7 | Warner Bros. | false | false |
| 9 | 9 | The Hurt Locker | $17,400 | -45.1% | 10 | -3 | $1,740 | $386,061 | 6 | Cineplex | false | false |
| 10 | 6 | Percy Jackson & the Olympians: The Lightning Thief | $15,719 | -65% | 39 | -12 | $403 | $824,531 | 6 | 20th Century Fox International | false | false |
| 11 | 10 | Precious | $15,708 | -48.2% | 15 | -2 | $1,047 | $280,945 | 5 | Cine Colombia | false | false |
| 12 | 23 | Law Abiding Citizen | $14,691 | +488.8% | 23 | -6 | $638 | $261,521 | 4 | Cineplex | false | false |
| 13 | 11 | Everybody's Fine | $10,256 | -64.8% | 16 | -1 | $641 | $47,624 | 2 | Walt Disney Pictures | false | false |
| 14 | 7 | The Wolfman | $9,107 | -74.8% | 8 | -30 | $1,138 | $1,025,487 | 6 | United International Pictures | false | false |
| 15 | 12 | Tooth Fairy | $8,361 | -69.2% | 28 | -8 | $298 | $1,104,368 | 9 | 20th Century Fox International | false | false |
| 16 | 16 | The Imaginarium of Doctor Parnassus | $6,593 | -48.2% | 8 | -1 | $824 | $54,280 | 3 | Sony Pictures Releasing | false | false |
| 17 | 15 | Cirque du Freak: The Vampire's Assistant | $5,992 | -54.7% | 7 | -2 | $856 | $138,242 | 5 | United International Pictures | false | false |
| 18 | 17 | Old Dogs | $5,454 | -26.4% | 12 | -4 | $454 | $1,164,568 | 11 | Walt Disney Pictures | false | false |
| 19 | - | A Prophet | $4,549 | - | 3 | - | $1,516 | $4,549 | 1 | Sony Pictures Releasing | true | false |
| 20 | 14 | Valentine's Day | $4,115 | -75% | 8 | -12 | $514 | $397,455 | 6 | Warner Bros. | false | false |
| 21 | - | A Serious Man | $3,988 | - | 5 | - | $797 | $3,988 | 1 | United International Pictures | true | false |
| 22 | 18 | The White Ribbon | $3,853 | -45.8% | 3 | - | $1,284 | $24,318 | 3 | - | false | false |
| 23 | - | Giant | $3,420 | - | 3 | - | $1,140 | $3,420 | 1 | Cine Colombia | true | false |
| 24 | 20 | The Men Who Stare at Goats | $2,048 | -57.6% | 3 | - | $682 | $8,633 | 2 | Sony Pictures Releasing | false | false |
| 25 | 24 | Broken Embraces | $1,496 | +22.9% | 2 | -1 | $748 | $104,357 | 7 | United International Pictures | false | false |
| 26 | 21 | Ninja Assassin | $1,023 | -66.2% | 3 | -4 | $341 | $146,524 | 8 | Warner Bros. | false | false |
| 27 | 29 | Alvin and the Chipmunks: The Squeakquel | $1,018 | +9.3% | 7 | - | $145 | $1,400,603 | 12 | 20th Century Fox International | false | false |
| 28 | 25 | The Soloist | $816 | -27.9% | 3 | -3 | $272 | $68,737 | 10 | United International Pictures | false | false |
| 29 | 19 | The Lovely Bones | $679 | -90.3% | 3 | -12 | $226 | $109,827 | 5 | United International Pictures | false | false |
| 30 | 22 | An Education | $295 | -89.3% | 2 | -4 | $147 | $50,408 | 5 | Sony Pictures Releasing | false | false |
