| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $163,564 | -59.9% | 55 | -5 | $2,973 | $1,789,003 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Green Zone | $154,653 | -45.5% | 44 | +20 | $3,514 | $1,789,003 | 2 | United International Pictures | false | false |
| 3 | - | How to Train Your Dragon | $130,497 | - | 47 | - | $2,776 | $130,497 | - | United International Pictures | - | false |
| 4 | 3 | Shutter Island | $32,176 | -56.8% | 16 | -2 | $2,011 | $516,445 | 3 | United International Pictures | false | false |
| 5 | 4 | The Wolfman | $18,311 | -55.3% | 9 | -11 | $2,034 | $1,006,830 | 5 | United International Pictures | false | false |
| 6 | 5 | Percy Jackson & the Olympians: The Lightning Thief | $12,523 | -47.2% | 7 | -5 | $1,789 | $1,420,390 | 6 | 20th Century Fox International | false | false |
| 7 | - | It's Complicated | $8,059 | - | 17 | - | $474 | $8,059 | - | United International Pictures | - | false |
| 8 | 6 | Avatar | $6,226 | -23.2% | 4 | +1 | $1,556 | $5,921,847 | 14 | 20th Century Fox International | false | false |
| 9 | 8 | Ninja Assassin | $5,164 | -25.1% | 2 | +1 | $2,582 | $1,858,889 | 17 | Warner Bros. | false | false |
| 10 | 9 | Up in the Air | $2,610 | -60.8% | 1 | -4 | $2,610 | $148,267 | 4 | United International Pictures | false | false |
| 11 | 7 | Sherlock Holmes | $2,356 | -68% | 1 | -2 | $2,356 | $2,163,216 | 12 | Warner Bros. | false | false |
| 12 | 10 | Legion | $904 | -85.3% | 1 | -4 | $904 | $668,643 | 8 | Sony Pictures Releasing | false | false |
