| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $4,307,666 | -48.2% | 589 | -57 | $7,313 | $34,257,368 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Loose Cannons | $2,093,612 | -26.8% | 423 | -4 | $4,949 | $6,132,727 | 2 | 01 Distribution | false | false |
| 3 | - | It's Complicated | $1,662,788 | - | 302 | - | $5,505 | $1,662,788 | 1 | United International Pictures | true | false |
| 4 | 3 | Shutter Island | $1,128,743 | -37.7% | 256 | -118 | $4,409 | $7,299,459 | 3 | Medusa Distribuzione | false | false |
| 5 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $1,087,717 | -33.1% | 287 | -1 | $3,789 | $3,085,786 | 2 | 20th Century Fox International | false | false |
| 6 | - | Edge of Darkness | $871,976 | - | 272 | - | $3,205 | $871,976 | 1 | 01 Distribution | true | false |
| 7 | - | Tutto l'amore del mondo | $699,892 | - | 268 | - | $2,611 | $699,892 | 1 | Medusa Distribuzione | true | false |
| 8 | 5 | Genitori & figli:) - Agitare bene prima dell'uso | $563,406 | -56.9% | 202 | -117 | $2,789 | $10,855,227 | 4 | Filmauro | false | false |
| 9 | 7 | Invictus | $403,076 | -52.9% | 130 | -116 | $3,100 | $7,804,477 | 4 | Warner Bros. | false | false |
| 10 | 8 | Avatar | $391,565 | -42.7% | 73 | -36 | $5,363 | $87,702,263 | 10 | 20th Century Fox International | false | false |
| 11 | 6 | Valentine's Day | $353,063 | -65.2% | 217 | -78 | $1,627 | $1,695,935 | 2 | Warner Bros. | false | false |
| 12 | - | A Prophet | $226,064 | - | 81 | - | $2,790 | $226,064 | 1 | BIM Distribuzione | true | false |
| 13 | 9 | Legion | $171,494 | -58.1% | 114 | -11 | $1,504 | $720,946 | 2 | Sony Pictures Releasing | false | false |
| 14 | 13 | The Concert | $161,099 | -19.7% | 47 | -5 | $3,427 | $3,973,581 | 7 | BIM Distribuzione | false | false |
| 15 | 11 | La valigia sul letto | $121,648 | -47.3% | 39 | -46 | $3,119 | $455,826 | 2 | Medusa Distribuzione | false | false |
| 16 | 14 | Women Without Men | $72,968 | -30.3% | 33 | - | $2,211 | $221,759 | 2 | BIM Distribuzione | false | false |
| 17 | - | I Am Love | $68,337 | - | 6 | - | $11,389 | $70,017 | 1 | Mikado Film | true | false |
| 18 | 12 | Chloe | $58,063 | -71.7% | 43 | -44 | $1,350 | $348,325 | 2 | Eagle Pictures | false | false |
| 19 | 15 | Partir | $48,212 | -37.3% | 26 | -9 | $1,854 | $354,470 | 3 | Teodora Film | false | false |
| 20 | 10 | The Book of Eli | $34,284 | -86.5% | 23 | -75 | $1,490 | $3,916,301 | 4 | 01 Distribution | false | false |
| 21 | 17 | Alvin and the Chipmunks: The Squeakquel | $28,364 | -13.9% | 40 | -11 | $709 | $8,197,134 | 8 | 20th Century Fox International | false | false |
| 22 | 18 | The Youngest Son | $19,450 | -37.5% | 16 | -5 | $1,215 | $2,848,577 | 5 | Medusa Distribuzione | false | false |
| 23 | 22 | The Man Who Will Come | $17,341 | -12.7% | 10 | +2 | $1,734 | $1,528,949 | 9 | Mikado Film | false | false |
| 24 | 20 | The First Beautiful Thing | $17,042 | -21.9% | 7 | -2 | $2,434 | $8,690,344 | 10 | Medusa Distribuzione | false | false |
| 25 | 21 | Crazy Heart | $11,421 | -45.6% | 10 | - | $1,142 | $80,114 | 3 | 20th Century Fox International | false | false |
| 26 | 24 | Up in the Air | $9,664 | -30% | 5 | -1 | $1,932 | $7,642,800 | 9 | United International Pictures | false | false |
| 27 | 28 | Incendiary | $9,113 | -8.5% | 6 | -1 | $1,518 | $81,058 | 4 | N/A | false | false |
| 28 | 29 | Diamond 13 | $9,064 | -3.1% | 6 | - | $1,510 | $59,550 | 3 | N/A | false | false |
| 29 | 19 | The Hurt Locker | $8,588 | -70% | 6 | -8 | $1,431 | $234,231 | 76 | Warner Bros. | false | false |
| 30 | 23 | Lilly the Witch: The Dragon and the Magic Book | $8,555 | -45.6% | 13 | -19 | $658 | $1,233,899 | 6 | Walt Disney Pictures | false | false |
| 31 | 27 | An Education | $8,151 | -23.7% | 10 | -4 | $815 | $512,338 | 7 | Sony Pictures Releasing | false | false |
| 32 | - | A Single Man | $7,784 | - | 3 | - | $2,594 | $1,531,617 | 10 | N/A | false | false |
| 33 | 25 | Soul Kitchen | $6,790 | -42.7% | 3 | -2 | $2,263 | $2,323,095 | 11 | BIM Distribuzione | false | false |
| 34 | 32 | Revanche | $6,287 | -17.1% | 8 | - | $785 | $64,694 | 3 | Fandango | false | false |
| 35 | 34 | Did You Hear About the Morgans? | $2,308 | -61.8% | 8 | -12 | $288 | $2,561,420 | 5 | Sony Pictures Releasing | false | false |
| 36 | 36 | Cloudy with a Chance of Meatballs | $2,257 | +32.5% | 7 | -4 | $322 | $8,521,015 | 13 | Sony Pictures Releasing | false | false |
