| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $409,797 | -44.9% | 93 | +1 | $4,406 | $2,508,485 | 3 | Walt Disney Pictures | false | false |
| 2 | - | How to Train Your Dragon | $180,894 | - | 21 | - | $8,614 | $180,894 | 1 | United International Pictures | true | false |
| 3 | - | The Book of Eli | $177,622 | - | 30 | - | $5,920 | $177,622 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | Miss You Like Crazy | $123,756 | -47.6% | 45 | -30 | $2,750 | $2,990,350 | 4 | Star Cinema | false | false |
| 5 | - | When in Rome | $98,159 | - | 50 | - | $1,963 | $98,159 | 1 | Walt Disney Pictures | true | false |
| 6 | 3 | Green Zone | $85,597 | -14.8% | 25 | - | $3,423 | $226,059 | 2 | United International Pictures | false | false |
| 7 | 4 | Remember Me | $47,533 | -35.3% | 45 | - | $1,056 | $148,607 | 2 | Pioneer Films | false | false |
| 8 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $22,794 | -32.8% | 16 | -14 | $1,424 | $1,992,657 | 6 | 20th Century Fox International | false | false |
| 9 | 6 | Cop Out | $16,719 | -58.8% | 27 | -23 | $619 | $235,446 | 3 | Warner Bros. | false | false |
| 10 | 8 | The Fourth Kind | $12,968 | -37.2% | 15 | -5 | $864 | $96,585 | 3 | Viva International Pictures | false | false |
| 11 | 5 | Extraordinary Measures | $10,927 | -84.1% | 19 | -21 | $575 | $97,970 | 2 | Sony Pictures Releasing | false | false |
| 12 | 19 | Invictus | $5,215 | +417.9% | 11 | +8 | $474 | $63,380 | 5 | Warner Bros. | false | false |
| 13 | 12 | From Paris with Love | $3,947 | -68.7% | 18 | -7 | $219 | $189,591 | 4 | Viva International Pictures | false | false |
| 14 | 9 | The Wolfman | $3,524 | -81.7% | 3 | -12 | $1,174 | $580,271 | 6 | United International Pictures | false | false |
| 15 | 10 | Avatar | $2,979 | -81.2% | 2 | - | $1,489 | $5,881,594 | 14 | 20th Century Fox International | false | false |
| 16 | 11 | Up in the Air | $2,354 | -85% | 4 | -6 | $588 | $77,391 | 3 | United International Pictures | false | false |
| 17 | 15 | Armored | $1,460 | -67.6% | 4 | -6 | $365 | $106,158 | 4 | Sony Pictures Releasing | false | false |
| 18 | 16 | It's Complicated | $987 | -60.4% | 2 | -6 | $493 | $80,762 | 4 | United International Pictures | false | false |
| 19 | 22 | Cirque du Freak: The Vampire's Assistant | $369 | -36% | 1 | -1 | $369 | $254,860 | 8 | United International Pictures | false | false |
| 20 | 17 | Cloudy with a Chance of Meatballs | $303 | -83.5% | 1 | - | $303 | $261,686 | 8 | Sony Pictures Releasing | false | false |
| 21 | 14 | Valentine's Day | $175 | -97.8% | 1 | -6 | $175 | $735,349 | 6 | Warner Bros. | false | false |
| 22 | 18 | Case 39 | $56 | -96.7% | 1 | -3 | $56 | $66,838 | 7 | United International Pictures | false | false |
