| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $454,003 | -59.6% | 128 | -1 | $3,546 | $6,160,301 | 4 | Walt Disney Pictures | false | false |
| 2 | - | How to Train Your Dragon | $403,513 | - | 118 | - | $3,419 | $403,513 | 1 | Paramount Pictures International | true | false |
| 3 | 2 | Shutter Island | $178,235 | -24.2% | 43 | - | $4,145 | $916,299 | 3 | Paramount Pictures International | false | false |
| 4 | 3 | The Book of Eli | $93,134 | -45.7% | 41 | - | $2,271 | $341,613 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | Brothers | $62,097 | - | 34 | - | $1,826 | $62,097 | 1 | Distribution Company | true | false |
| 6 | 4 | Edge of Darkness | $55,737 | -36.3% | 64 | - | $870 | $1,021,144 | 5 | Warner Bros. | false | false |
| 7 | - | The Rebound | $54,379 | - | 26 | - | $2,091 | $54,379 | 1 | Alfa Films | true | false |
| 8 | 5 | The Blind Side | $40,785 | -52.6% | 32 | +2 | $1,274 | $162,626 | 2 | Warner Bros. | false | false |
| 9 | 8 | Paco | $33,030 | -49% | 40 | -2 | $825 | $132,281 | 2 | Primer Plano Film Group | false | false |
| 10 | 7 | Everybody's Fine | $30,234 | -56.6% | 28 | +2 | $1,079 | $131,396 | 2 | Walt Disney Pictures | false | false |
| 11 | 6 | The Hurt Locker | $29,911 | -64.4% | 49 | +1 | $610 | $762,840 | 8 | Distribution Company | false | false |
| 12 | 10 | Did You Hear About the Morgans? | $22,630 | -51.9% | 24 | -6 | $942 | $250,316 | 3 | Sony Pictures Releasing | false | false |
| 13 | 24 | Couples Retreat | $14,085 | +91.6% | 15 | +5 | $939 | $132,946 | 4 | Universal Pictures International (UPI) | false | false |
| 14 | 9 | Avatar | $11,251 | -76.6% | 16 | -14 | $703 | $13,422,538 | 13 | 20th Century Fox International | false | false |
| 15 | - | Coco 2010 Re-release | $10,608 | - | 9 | - | $1,178 | $10,608 | 1 | Impacto Cine | true | false |
| 16 | 14 | The Girl with the Dragon Tattoo | $10,084 | -45.5% | 15 | -8 | $672 | $260,906 | 6 | N/A | false | false |
| 17 | 21 | Bad Lieutenant: Port of Call New Orleans | $9,693 | +12.3% | 23 | +5 | $421 | $158,131 | 4 | Distribution Company | false | false |
| 18 | 16 | Precious | $7,070 | -53.2% | 14 | - | $505 | $277,022 | 7 | N/A | false | false |
| 19 | 11 | The Wolfman | $6,890 | -70.7% | 21 | -27 | $328 | $1,113,992 | 7 | Universal Pictures International (UPI) | false | false |
| 20 | 18 | The Secret in Their Eyes | $6,612 | -53.1% | 22 | -13 | $300 | $9,293,521 | 33 | Distribution Company | false | false |
| 21 | 13 | Crazy Heart | $5,974 | -72.9% | 11 | +1 | $543 | $92,328 | 3 | 20th Century Fox International | false | false |
| 22 | 19 | A Serious Man | $5,609 | -50.7% | 8 | -3 | $701 | $140,894 | 5 | Universal Pictures International (UPI) | false | false |
| 23 | 12 | Percy Jackson & the Olympians: The Lightning Thief | $5,099 | -77.2% | 25 | -20 | $203 | $721,267 | 6 | 20th Century Fox International | false | false |
| 24 | 22 | Valentine's Day | $4,255 | -48.4% | 13 | -3 | $327 | $882,919 | 7 | Warner Bros. | false | false |
| 25 | 26 | Our Beloved Month of August | $4,240 | -12.4% | 4 | - | $1,060 | $34,824 | 4 | N/A | false | false |
| 26 | 20 | The Imaginarium of Doctor Parnassus | $4,025 | -60.9% | 8 | +2 | $503 | $239,266 | 5 | Sony Pictures Releasing | false | false |
| 27 | 15 | 9 | $3,672 | -79.6% | 18 | -1 | $204 | $31,722 | 2 | Distribution Company | false | false |
| 28 | 17 | Invictus | $3,247 | -78.5% | 17 | -17 | $191 | $982,233 | 9 | Warner Bros. | false | false |
| 29 | 23 | Old Dogs | $1,271 | -83.3% | 10 | -22 | $127 | $1,511,980 | 10 | Walt Disney Pictures | false | false |
| 30 | 31 | The Princess and the Frog | $1,181 | -42.7% | 7 | -3 | $168 | $1,929,082 | 12 | Walt Disney Pictures | false | false |
| 31 | 27 | The Lovely Bones | $995 | -71.7% | 1 | -4 | $995 | $211,753 | 6 | Paramount Pictures International | false | false |
| 32 | 33 | The Young Victoria | $881 | -48.4% | 3 | - | $293 | $183,079 | 11 | Distribution Company | false | false |
| 33 | 28 | The Last Days of Emma Blank | $720 | -78% | 1 | -2 | $720 | $4,684 | 2 | CDI Films | false | false |
| 34 | 30 | Alvin and the Chipmunks: The Squeakquel | $656 | -74.1% | 5 | - | $131 | $1,093,310 | 10 | 20th Century Fox International | false | false |
| 35 | 37 | Mongol: The Rise of Genghis Khan | $539 | -51.9% | 2 | -1 | $269 | $8,064 | 3 | Alfa Films | false | false |
| 36 | 25 | Astro Boy | $451 | -92.6% | 4 | -13 | $112 | $174,307 | 9 | Alfa Films | false | false |
| 37 | 47 | Let it Rain | $264 | +915.4% | 1 | - | $264 | $140,668 | 16 | Alfa Films | false | false |
| 38 | 34 | Zombieland | $248 | -83.4% | 1 | -4 | $248 | $105,910 | 9 | Sony Pictures Releasing | false | false |
| 39 | 43 | Un fueguito. La historia de César Milstein | $243 | -47.2% | 1 | - | $243 | $11,892 | 3 | Primer Plano Film Group | false | false |
| 40 | 36 | An Education | $230 | -79.6% | 3 | -3 | $76 | $185,791 | 8 | Sony Pictures Releasing | false | false |
| 41 | 29 | Birds of Paradise | $226 | -92.7% | 5 | -8 | $45 | $189,643 | 6 | Sony Pictures Releasing | false | false |
| 42 | 35 | Daybreakers | $197 | -83.8% | 1 | -3 | $197 | $390,686 | 10 | Distribution Company | false | false |
| 43 | 44 | Nora's Will | $196 | -33.1% | 1 | - | $196 | $53,942 | 9 | Primer Plano Film Group | false | false |
| 44 | 38 | Sherlock Holmes | $176 | -80.8% | 1 | -4 | $176 | $2,701,752 | 11 | Warner Bros. | false | false |
| 45 | 48 | Inglourious Basterds | $130 | +1,200% | 1 | - | $130 | $1,222,810 | 30 | Universal Pictures International (UPI) | false | false |
| 46 | 42 | Up in the Air | $119 | -77% | 1 | -5 | $119 | $724,253 | 10 | Paramount Pictures International | false | false |
| 47 | 49 | Broken Embraces | $109 | +2,080% | 1 | - | $109 | $518,536 | 26 | Universal Pictures International (UPI) | false | false |
| 48 | 46 | Tooth Fairy | $9 | -82% | 1 | - | $9 | $482,523 | 8 | 20th Century Fox International | false | false |
