| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | How to Train Your Dragon | $283,417 | - | 66 | - | $4,294 | $287,228 | 1 | United International Pictures | true | false |
| 2 | - | Legion | $113,512 | - | 26 | - | $4,365 | $113,512 | 1 | Sony Pictures Releasing | true | false |
| 3 | 3 | The Hurt Locker | $32,367 | -30.8% | 19 | +2 | $1,703 | $283,461 | 6 | N/A | false | false |
| 4 | 1 | Avatar | $30,715 | -70.3% | 23 | -4 | $1,335 | $10,241,745 | 15 | 20th Century Fox International | false | false |
| 5 | - | The Box | $23,755 | - | 17 | - | $1,397 | $23,755 | 1 | N/A | true | false |
| 6 | 2 | Percy Jackson & the Olympians: The Lightning Thief | $22,531 | -57.7% | 30 | -5 | $751 | $753,524 | 7 | 20th Century Fox International | false | false |
| 7 | 7 | The Blind Side | $19,939 | -18.7% | 8 | - | $2,492 | $53,549 | 2 | Warner Bros. | false | false |
| 8 | 9 | 500 Days of Summer | $17,579 | -18.1% | 8 | +1 | $2,197 | $80,391 | 3 | 20th Century Fox International | false | false |
| 9 | 6 | [Rec]² | $15,144 | -50.9% | 16 | +2 | $946 | $59,450 | 2 | N/A | false | false |
| 10 | 4 | The Wolfman | $14,958 | -62.3% | 26 | -5 | $575 | $745,598 | 7 | United International Pictures | false | false |
| 11 | 5 | Alvin and the Chipmunks: The Squeakquel | $13,010 | -62.6% | 22 | -13 | $591 | $1,381,034 | 9 | 20th Century Fox International | false | false |
| 12 | 8 | My Best Friend's Girl | $12,239 | -45.5% | 14 | -1 | $874 | $44,663 | 2 | Transeuropa | false | false |
| 13 | 10 | The Lovely Bones | $11,000 | -44.8% | 14 | -6 | $785 | $253,546 | 6 | United International Pictures | false | false |
| 14 | - | Let the Right One In | $8,836 | - | 5 | - | $1,767 | $8,836 | 1 | N/A | true | false |
| 15 | 12 | The Haunting in Connecticut | $5,301 | -38.7% | 4 | -1 | $1,325 | $178,550 | 11 | Transeuropa | false | false |
| 16 | 13 | Valentine's Day | $4,201 | -48.4% | 4 | -7 | $1,050 | $315,001 | 7 | Warner Bros. | false | false |
| 17 | 11 | Halloween II | $3,771 | -71.1% | 6 | -9 | $628 | $54,926 | 3 | N/A | false | false |
| 18 | 21 | Up in the Air | $3,704 | +9.7% | 2 | -2 | $1,852 | $146,971 | 8 | United International Pictures | false | false |
| 19 | 14 | Precious | $1,760 | -75.1% | 1 | -3 | $1,760 | $42,718 | 5 | N/A | false | false |
| 20 | 17 | Ponyo | $1,750 | -65.6% | 6 | +1 | $291 | $33,896 | 5 | Andes Films | false | false |
| 21 | 20 | The Imaginarium of Doctor Parnassus | $1,660 | -51.3% | 3 | -1 | $553 | $86,155 | 9 | Sony Pictures Releasing | false | false |
| 22 | 22 | Invictus | $1,027 | -64.7% | 3 | -2 | $342 | $198,152 | 8 | Warner Bros. | false | false |
| 23 | 19 | Welcome to the Sticks | $894 | -79.6% | 1 | -3 | $894 | $16,180 | 3 | N/A | false | false |
| 24 | 25 | Everybody's Fine | $722 | -68.8% | 4 | -2 | $180 | $29,717 | 5 | Walt Disney Pictures | false | false |
| 25 | 16 | Sherlock Holmes | $570 | -89.9% | 1 | -8 | $570 | $1,263,442 | 10 | Warner Bros. | false | false |
| 26 | 27 | Astro Boy | $406 | -81.7% | 8 | -2 | $50 | $188,580 | 10 | N/A | false | false |
| 27 | 29 | Tooth Fairy | $353 | -71.1% | 1 | - | $353 | $526,596 | 12 | 20th Century Fox International | false | false |
| 28 | 23 | Nine | $256 | -90.7% | 1 | -6 | $256 | $48,737 | 6 | Sony Pictures Releasing | false | false |
| 29 | 30 | An Education | $192 | -51.1% | 2 | -3 | $96 | $26,704 | 10 | Sony Pictures Releasing | false | false |
| 30 | 28 | Couples Retreat | $75 | -95.5% | 1 | -6 | $75 | $46,735 | 5 | United International Pictures | false | false |
