| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $539,610 | -40.4% | 142 | -15 | $3,800 | $4,947,393 | 4 | Walt Disney Pictures | false | false |
| 2 | - | How to Train Your Dragon | $344,718 | - | 108 | - | $3,191 | $344,718 | 1 | United International Pictures | true | false |
| 3 | 2 | The Book of Eli | $152,268 | -22.3% | 75 | - | $2,030 | $472,500 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | The Blind Side | $92,680 | - | 47 | - | $1,971 | $92,680 | 1 | Warner Bros. | true | false |
| 5 | - | Did You Hear About the Morgans? | $80,685 | - | 50 | - | $1,613 | $80,685 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | Shutter Island | $46,182 | -33.4% | 27 | -6 | $1,710 | $280,624 | 3 | United International Pictures | false | false |
| 7 | - | Remember Me | $39,997 | - | 30 | - | $1,333 | $39,997 | 1 | Cine Colombia | true | false |
| 8 | 3 | Edge of Darkness | $31,381 | -62.7% | 37 | -12 | $848 | $356,393 | 3 | Warner Bros. | false | false |
| 9 | 5 | Avatar | $30,557 | -39.6% | 9 | -1 | $3,395 | $13,529,991 | 15 | 20th Century Fox International | false | false |
| 10 | 9 | The Hurt Locker | $10,608 | -39% | 11 | +1 | $964 | $210,950 | 7 | Cineplex | false | false |
| 11 | 6 | [Rec]² | $9,434 | -64.1% | 10 | -10 | $943 | $212,573 | 4 | Cine Colombia | false | false |
| 12 | 10 | Percy Jackson & the Olympians: The Lightning Thief | $8,906 | -43.3% | 22 | -17 | $404 | $843,332 | 7 | 20th Century Fox International | false | false |
| 13 | - | The Anarchist's Wife | $5,689 | - | 4 | - | $1,422 | $5,689 | 1 | Cineplex | true | false |
| 14 | 15 | Tooth Fairy | $5,642 | -32.5% | 20 | -8 | $282 | $1,117,119 | 10 | 20th Century Fox International | false | false |
| 15 | 7 | Couples Retreat | $4,569 | -75.8% | 5 | -18 | $913 | $207,580 | 5 | United International Pictures | false | false |
| 16 | 14 | The Wolfman | $4,236 | -53.5% | 4 | -4 | $1,059 | $1,035,011 | 7 | United International Pictures | false | false |
| 17 | 18 | Old Dogs | $2,863 | -47.5% | 6 | -6 | $477 | $1,172,163 | 12 | Walt Disney Pictures | false | false |
| 18 | 13 | Everybody's Fine | $2,657 | -74.1% | 13 | -3 | $204 | $56,896 | 3 | Walt Disney Pictures | false | false |
| 19 | 12 | Law Abiding Citizen | $2,475 | -83.2% | 2 | -21 | $1,237 | $273,407 | 5 | Cineplex | false | false |
| 20 | 11 | Precious | $2,445 | -84.4% | 5 | -10 | $489 | $293,025 | 6 | Cine Colombia | false | false |
| 21 | 8 | Invictus | $1,644 | -90.6% | 7 | -18 | $234 | $398,377 | 8 | Warner Bros. | false | false |
| 22 | 16 | The Imaginarium of Doctor Parnassus | $1,603 | -75.7% | 2 | -6 | $801 | $60,221 | 4 | Sony Pictures Releasing | false | false |
| 23 | 22 | The White Ribbon | $1,433 | -62.8% | 4 | +1 | $358 | $28,033 | 4 | - | false | false |
| 24 | 19 | A Prophet | $1,218 | -73.2% | 3 | - | $406 | $8,658 | 2 | Sony Pictures Releasing | false | false |
| 25 | 21 | A Serious Man | $1,028 | -74.2% | 2 | -3 | $514 | $7,407 | 2 | United International Pictures | false | false |
| 26 | 27 | Alvin and the Chipmunks: The Squeakquel | $758 | -25.5% | 7 | - | $108 | $1,401,876 | 13 | 20th Century Fox International | false | false |
| 27 | 24 | The Men Who Stare at Goats | $674 | -67.1% | 1 | -2 | $674 | $10,590 | 3 | Sony Pictures Releasing | false | false |
