| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $7,279,830 | -34.8% | 525 | -8 | $13,866 | $45,797,617 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Bounty Hunter | $3,086,405 | - | 394 | - | $7,833 | $3,086,405 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Shutter Island | $2,723,341 | -20.4% | 419 | +3 | $6,499 | $8,234,862 | 2 | Paramount Pictures International | false | false |
| 4 | - | I Love You Phillip Morris | $1,601,147 | - | 342 | - | $4,681 | $1,601,147 | 1 | Entertainment One | true | false |
| 5 | 3 | Green Zone | $1,535,614 | -51.6% | 419 | - | $3,664 | $5,896,526 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | - | The Spy Next Door 2010 Re-release | $1,048,548 | - | 332 | - | $3,158 | $1,048,548 | 1 | Paramount Pictures International | true | false |
| 7 | 4 | Avatar | $669,554 | -31.1% | 226 | -45 | $2,962 | $136,065,473 | 14 | 20th Century Fox International | false | false |
| 8 | 6 | The Girl with the Dragon Tattoo | $464,285 | -19.3% | 126 | +12 | $3,684 | $1,373,999 | 2 | Momentum Pictures | false | false |
| 9 | 5 | Hachi: A Dog's Tale | $390,693 | -42% | 126 | -190 | $3,100 | $1,373,999 | 2 | Entertainment Film Distributors | false | false |
| 10 | 9 | The Princess and the Frog | $218,751 | -35.5% | 386 | -56 | $566 | $16,430,311 | 6 | Walt Disney Pictures | false | false |
| 11 | 7 | The Lovely Bones | $212,455 | -59.3% | 256 | -103 | $829 | $9,301,424 | 5 | Paramount Pictures International | false | false |
| 12 | - | Old Dogs | $195,822 | - | 205 | - | $955 | $195,822 | 1 | Walt Disney Pictures | true | false |
| 13 | 10 | Percy Jackson & the Olympians: The Lightning Thief | $151,199 | -49.1% | 293 | -104 | $516 | $11,035,357 | 6 | 20th Century Fox International | false | false |
| 14 | 12 | Crazy Heart | $128,321 | -45.1% | 110 | -13 | $1,166 | $1,479,176 | 5 | 20th Century Fox International | false | false |
| 15 | 8 | The Crazies | $124,123 | -67.7% | 180 | -116 | $689 | $4,889,087 | 4 | Paramount Pictures International | false | false |
