| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Alice in Wonderland | $29,017 | -21.4% | 14 | +1 | $2,072 | $227,637 | 4 | Walt Disney Pictures | false | false |
| 2 | - | Remember Me | $24,343 | - | 9 | - | $2,704 | $24,343 | 1 | N/A | true | false |
| 3 | 1 | Shutter Island | $23,823 | -41.9% | 9 | - | $2,647 | $167,798 | 3 | United International Pictures | false | false |
| 4 | 3 | From Paris with Love | $13,832 | -41.3% | 6 | - | $2,305 | $45,170 | 2 | N/A | false | false |
| 5 | 5 | Leap Year | $10,662 | -36.7% | 6 | - | $1,777 | $33,777 | 2 | United International Pictures | false | false |
| 6 | 4 | Avatar | $9,156 | -51.5% | 9 | -2 | $1,017 | $1,627,155 | 15 | 20th Century Fox International | false | false |
| 7 | 6 | Percy Jackson & the Olympians: The Lightning Thief | $7,232 | -55.4% | 6 | - | $1,205 | $27,521 | 2 | 20th Century Fox International | false | false |
| 8 | 7 | The Blind Side | $5,581 | -39.7% | 6 | - | $930 | $74,594 | 4 | Warner Bros. | false | false |
| 9 | 9 | The Spy Next Door 2010 Re-release | $5,046 | -16.3% | 5 | - | $1,009 | $62,379 | 5 | N/A | false | false |
| 10 | 8 | Cloudy with a Chance of Meatballs | $3,979 | -56.5% | 12 | -3 | $331 | $151,058 | 8 | Sony Pictures Releasing | false | false |
| 11 | 13 | Invictus 2010 Re-release | $2,806 | -17.3% | 6 | - | $467 | $26,316 | 3 | Warner Bros. | false | false |
| 12 | 10 | Dear John | $2,071 | -47.1% | 5 | -1 | $414 | $99,856 | 6 | N/A | false | false |
| 13 | 11 | The Lovely Bones | $1,842 | -50.7% | 5 | -1 | $368 | $58,794 | 5 | United International Pictures | false | false |
| 14 | 15 | Crazy Heart | $1,168 | -23.2% | 1 | - | $1,168 | $3,054 | 2 | 20th Century Fox International | false | false |
